The Effect of Finasteride and Dutasteride on the Synthesis of Neurosteroids by Glioblastoma Cells

    December 2019 in “ Steroids ”
    Luis Manuel Pinacho-Garcia, R.A. Valdez, Araceli Navarrete … Marta C. Romano
    Studysummary This study found that the pharmacological inhibition of 5-α reductases with finasteride and dutasteride can reduce neurosteroid synthesis in glioblastoma-derived cell lines, potentially impacting GBM survival.
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    Research cited in this study 4

    1. Allopregnanolone Promotes Proliferation and Differential Gene Expression in Human Glioblastoma Cells Steroids · 2017
    2. Recent Advances in Drug Design and Drug Discovery for Androgen-Dependent Diseases Current Medicinal Chemistry · 2016
    3. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011
    4. Aromatase-Independent Testosterone Conversion Into Estrogenic Steroids Is Inhibited by a 5α-Reductase Inhibitor The Journal of Steroid Biochemistry and Molecular Biology · 2005

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