Mechanisms of Hepatocyte Attachment to Keratin Biomaterials

July 2011 in “ Biomaterials ”

Jillian R. Richter, Roche C. de Guzman, Mark Van Dyke

keratin biomaterials hepatocytes β(1)-integrins β(2)-integrins asialoglycoprotein receptor ASGPR phosphorylated-focal adhesion kinase keratin integrins focal adhesion kinase

Studysummary This study observed that hepatocyte adhesion to human hair keratin biomaterials was mediated by the hepatic ASGPR, as blocking this receptor reduced cell attachment.

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This study found that scaffolds made from human hair proteins supported better cell growth and interactions than control surfaces, indicating potential use in tissue engineering.

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This study found that a biomaterial gel made from human hair keratins facilitated nerve regeneration in an animal model, potentially matching the effectiveness of traditional autografts.

research Method for Chronological Recording of Antigen Appearance in Human Head-Hair Shafts and Its Use for Monitoring Glycation Products in Diabetes

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This study found that the novel dot-block method can effectively measure early- and advanced-glycation products in hair, suggesting its potential for monitoring diabetes progression and other chronic conditions.

research Hair Protein Glycation as a Long-Term Index of Blood Glucose in Diabetics

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research Glycation of Hair Protein in the Assessment of Long-Term Control of Blood Glucose

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This study suggests that measuring glycation in hair may serve as a useful indicator of long-term blood glucose control in diabetic patients.