Proteomics Demonstration That Histone H4 Is a Colchicine-Induced Retro-Modulator of Growth and Alkaline Phosphatase Activity in Hair Follicle Dermal Papilla Culture

    March 2011 in “ Journal of proteomics ”
    Ching Wu Hsia, Hao‐Ai Shui, Chih‐Yuan Wang … Min Tseng
    Studysummary This study found that exposing dermal papilla cells to sub-lethal doses of colchicine releases histone H4, which inhibits cell growth and decreases alkaline phosphatase activity, potentially explaining colchicine-induced hair loss.
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    Research cited in this study 9

    1. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    2. Biological Characterization of Cultured Dermal Papilla Cells and Hair Follicle Regeneration In Vitro and In Vivo Chinese Medical Journal · 2006
    3. A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice Journal of Investigative Dermatology · 2005
    4. Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla Journal of Investigative Dermatology · 2005
    5. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    6. Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla Journal of Investigative Dermatology · 2003
    7. Cutaneous Metabolism of Vitamin B-6 ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2003
    8. Role of Hair Papilla Cells in Induction and Regeneration Processes of Hair Follicles Wound Repair and Regeneration · 1998
    9. Induction of Follicle Formation and Hair Growth by Vibrissa Dermal Papillae Implanted into Rat Ear Wounds: Vibrissa-Type Fibres Are Specified Development · 1992

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    2. Proteomics Demonstration That Histone H4 Is a Colchicine-Induced Retro-Modulator of Growth and Alkaline Phosphatase Activity in Hair Follicle Dermal Papilla Culture Journal of proteomics · 2011
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    6. Alkaline Phosphatase Reaction in Hair Follicles of Male Beagle Dogs During Hair Cycle Stages Anatomia Histologia Embryologia · 1978