Mechanical Index-Guided Low Intensity Ultrasound Therapy for Hair Regeneration: Insights from Finite Element Modeling and In Vivo Experiments

    November 2025 in “ Physics of Fluids
    Sadegh Shurche, Manijhe Mokhtari‐Dizaji, Mansoureh Movahedin … Ehsan Taghiabadi
    Studysummary In this study, low-intensity ultrasound was investigated as a noninvasive method for promoting hair regrowth in androgenetic alopecia using C57BL/6 male mice, revealing that specific frequencies and intensities can safely enhance hair regrowth compared to controls by optimizing mechanical effects without causing unsafe cavitation.
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    Research cited in this study 15

    1. High-Intensity Focused Ultrasound Application to the Scalp to Improve Androgenetic Alopecia in an Adult Woman Journal of Craniofacial Surgery Open · 2025
    2. Epidemiological Landscape of Androgenetic Alopecia in the US: An All of Us Cross-Sectional Study PLoS ONE · 2025
    3. Prospective Evaluation of Blood Pressure, Heart Rate, and Side Effects in Hypertensive Patients Using Low-Dose Oral Minoxidil for Hair Loss Journal of the American Academy of Dermatology · 2024
    4. Updated Review of Treatment of Androgenetic Alopecia Facial plastic surgery clinics of North America · 2024
    5. The Biology and Genomics of Human Hair Follicles: A Focus on Androgenetic Alopecia International Journal of Molecular Sciences · 2024
    6. Impact of Hair Transplantation on Quality of Life Aesthetic Plastic Surgery · 2023
    7. Psychosocial Impact of Androgenetic Alopecia on Men: A Systematic Review and Meta-Analysis Psychology, Health & Medicine · 2023
    8. Low-Intensity Ultrasound as a Potential Intervention Strategy to Protect Human Scalp Hair Follicles from Taxane-Induced Toxicity Journal of Investigative Dermatology · 2023
    9. Induction of Hair Growth in Hair Follicle Cells and Organ Cultures Upon Treatment with 30 kHz Frequency Inaudible Sound via Cell Proliferation and Antiapoptotic Effects Biomedical Reports · 2022
    10. Low-Frequency Dual-Frequency Ultrasound-Mediated Microbubble Cavitation for Transdermal Minoxidil Delivery and Hair Growth Enhancement Scientific Reports · 2020
    11. Ultrasound-Activated Particles as CRISPR/Cas9 Delivery System for Androgenic Alopecia Therapy Biomaterials · 2019
    12. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    13. New Hair From Healing Wounds Nature · 2007
    14. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    15. The Catalog of Human Hair Keratins Journal of Biological Chemistry · 2001