Time to Loss of Response for Dupilumab in Ophiasis-Pattern Alopecia Areata

The document reports on a 33-year-old woman with ophiasis-pattern alopecia areata who experienced significant hair regrowth after treatment with dupilumab. Despite various treatments over four years, none had sustained improvement beyond two months. After starting dupilumab, she showed visible hair growth within two weeks, and after 10 injections over six months, her Severity of Alopecia Tool (SALT-1) score decreased from 81.3 to 2.4, indicating substantial hair recovery. The patient maintained hair growth for six months post-treatment before relapsing. This case suggests that dupilumab can be an effective treatment for alopecia areata, with rapid response and sustained hair retention after therapy cessation. However, the need for larger, controlled studies is emphasized to validate these findings and determine the applicability to other forms of extensive alopecia areata.