TLDR Mycophenolate mofetil may safely help restore skin color in depigmentation conditions.
The study explores the effects of topical Mycophenolate mofetil (MMF) on hydroquinone-induced depigmentation in guinea pigs and mice, with a focus on its potential for treating vitiligo. MMF was shown to enhance pigmentation by increasing melanocytes and melanin in hair follicles, activating tyrosinase, and upregulating melanin-associated genes. It also activated the WNT signaling pathway, important for melanocyte differentiation and repigmentation. Conducted on 54 guinea pigs and C57/BL6 mice, the study found that MMF effectively mitigated depigmentation without adverse effects on liver and kidney function, suggesting it could be a promising and safe treatment for skin pigmentation disorders, though further research is needed for human application.
23 citations,
March 2017 in “PTR. Phytotherapy research/Phytotherapy research” Butin is effective in treating vitiligo in mice.
16 citations,
March 2015 in “Clinical and experimental dermatology” Mycophenolic acid may help treat hair loss by promoting hair growth and cell proliferation.
11 citations,
September 2014 in “International Journal of Molecular Sciences” Mycophenolate helps reverse hair loss effects caused by IFN-γ by activating a key hair growth pathway.
127 citations,
November 2010 in “Pigment cell & melanoma research” We need more research on human hair follicle pigmentation, not just mouse models.
10 citations,
May 2015 in “International Journal of Women's Dermatology” New treatments for skin and hair disorders in women of color address unique biological differences and include specific acne medications, sunscreens, skin lighteners, and hair care adjustments.
3 citations,
July 2017 in “Elsevier eBooks” Skin reactions are a common reason for emergency visits due to drug allergies, with some severe cases needing intensive care.
January 2017 in “Springer eBooks” The document explains various skin conditions and their treatments.
85 citations,
April 2007 in “Dermatologic Clinics” Some drugs can cause hair loss, change hair color and shape, or increase hair growth, and treatment may involve stopping the drug or using specific hair growth treatments.
