The Effect of Butin on the Vitiligo Mouse Model Induced by Hydroquinone

    March 2017 in “ PTR. Phytotherapy research/Phytotherapy research ”
    Shi‐Xia Huo, Qiong Wang, Xinmin Liu, GE Chun-hui, Li Gao, Xiaoming Peng, Ming Yan
    TLDR Butin is effective in treating vitiligo in mice.
    The study investigated the effects of butin, a component of Vernonia anthelmintica, on hydroquinone-induced vitiligo in mice. Mice were divided into six groups, including control, model, 8-MOP, and three butin dosage groups. Results showed that butin increased melanin-containing hair follicles, basal layer melanocytes, and melanin-containing epidermal cells, while also enhancing the expression of tyrosinase (TYR) and tyrosinase-related protein-1 (TRP-1). Additionally, butin decreased malondialdehyde (MDA) and cholinesterase (CHE) activity. These findings supported the use of butin for vitiligo treatment, suggesting its mechanisms involve boosting TYR and TRP-1 expression and reducing MDA and CHE activity.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 957 results

      community PP405 is nothing but a scam and Pelage know it.

      in Chat  78 upvotes 1 month ago
      PP405 is criticized for overhyped claims and cherry-picked data, with doubts about its effectiveness compared to minoxidil and finasteride. Many users express skepticism, emphasizing the need for more comprehensive trial results.

      community Reasons why Topical worked but Oral Minoxidil didn’t?

      in Minoxidil  16 upvotes 1 year ago
      Some people find topical minoxidil effective for hair loss, but oral minoxidil doesn't work for them, possibly due to absorption issues. Others have had better results with oral minoxidil, suggesting individual responses vary.

      community Posted this years ago but still getting questions!

      in Progress Pictures  326 upvotes 1 year ago
      The user successfully treated their hair loss using 1ml of minoxidil twice daily and dermarolling with a 1.5mm dermaroller once a week. They experienced noticeable results only after combining minoxidil with dermarolling, and they have not used finasteride.

      community My nuclear protocol (scary but very effective)

      in Treatment  81 upvotes 3 years ago
      A hair loss treatment protocol involving topical and oral medications such as Minoxidil, RU58841, Finasteride, Dutasteride, Melatonin, Zinc, Vitamin B6, NAC, Caffeine, Biotin, Ginseng, and Semen; other treatments including Microneedling, Laser Helmet, Nizoral shampoo, Scalp Massage and supplements like Vitamin C, Vitamin D, Fish Oil, and Biotin; and the potential side effects of using this protocol.

    Similar Research

    5 / 1000+ results