The Effect of Butin on the Vitiligo Mouse Model Induced by Hydroquinone

The study investigated the effects of butin, a component of Vernonia anthelmintica, on hydroquinone-induced vitiligo in mice. Mice were divided into six groups, including control, model, 8-MOP, and three butin dosage groups. Results showed that butin increased melanin-containing hair follicles, basal layer melanocytes, and melanin-containing epidermal cells, while also enhancing the expression of tyrosinase (TYR) and tyrosinase-related protein-1 (TRP-1). Additionally, butin decreased malondialdehyde (MDA) and cholinesterase (CHE) activity. These findings supported the use of butin for vitiligo treatment, suggesting its mechanisms involve boosting TYR and TRP-1 expression and reducing MDA and CHE activity.