TLDR Butin is effective in treating vitiligo in mice.
The study investigated the effects of butin, a component of Vernonia anthelmintica, on hydroquinone-induced vitiligo in mice. Mice were divided into six groups, including control, model, 8-MOP, and three butin dosage groups. Results showed that butin increased melanin-containing hair follicles, basal layer melanocytes, and melanin-containing epidermal cells, while also enhancing the expression of tyrosinase (TYR) and tyrosinase-related protein-1 (TRP-1). Additionally, butin decreased malondialdehyde (MDA) and cholinesterase (CHE) activity. These findings supported the use of butin for vitiligo treatment, suggesting its mechanisms involve boosting TYR and TRP-1 expression and reducing MDA and CHE activity.
78 citations,
August 2014 in “Anais Brasileiros de Dermatologia” New vitiligo treatments focus on controlling immune damage and restoring skin color.
450 citations,
January 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair color is determined by melanin produced and transferred in hair follicles.
2 citations,
November 2022 in “Frontiers in Pharmacology” Local healers in Addis Ababa use 81 medicinal plants, mainly from the Asteraceae family, to treat skin and general diseases, with Echinops kebericho being an endangered plant important in their practices.
39 citations,
January 2019 in “Cells” Gene therapy has potential as a future treatment for Hutchinson-Gilford progeria syndrome.
33 citations,
January 2018 in “The International Journal of Developmental Biology” Cell aging can be both good and bad for tissue repair.
9 citations,
July 2021 in “Journal of Natural Medicines” Over 150 new molecules with biological activities were found in traditional herbal medicines, some with potential for new drug development.
186 citations,
December 2012 in “Current opinion in cell biology” Keratin proteins are increasingly recognized as important for cell health and are linked to many diseases.
