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research Deficiency in Nucleotide Excision Repair Family Gene Activity, Especially ERCC3, Is Associated with Non-Pigmented Hair Fiber Growth

10 citations , May 2012 in “PloS one”

This study found that non-pigmented hair follicles have significantly lower expression of nucleotide excision repair genes, which may be associated with reduced melanin production capacity in these follicles.

research Regulatory pathway analysis of coat color genes in Mongolian horses

14 citations , September 2017 in “Hereditas”

This study found that differentially expressed genes in horses with white versus black coats may regulate coat color, providing insights into the genetics of skin melanin synthesis.

research 3,4,5-Tri-O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes

13 citations , March 2020 in “Frontiers in cell and developmental biology”

This study suggests that 3,4,5-tri-O-caffeoylquinic acid activates β-catenin to enhance pigmentation in mouse hair follicles, human melanocytes, and melanoma cells during the hair cycle's growth phase.

research Activity evaluation of epidermo-melanin unit and dermal damage in melasma

January 2016 in “UNESP Institutional Repository (São Paulo State University)”

This study suggests that the phenotype of melasma in women is influenced by structural and cellular changes across the epidermal-melanin unit, not just melanocyte hypertrophy, highlighting potential roles for dermal damage repair and fibroblast senescence.

research Therapeutic effects of topical Mycophenolate mofetil on hydroquinone-induced depigmentation in Guinea pigs and mice

August 2025 in “Annals of Medicine”

This study found that mycophenolate mofetil can enhance skin pigmentation in vitiligo models by activating the WNT signaling pathway and increasing melanin-related gene expression.

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community Prevention of age-related beard graying in humans by the topical application of Eriodictyon angustifolium extract

5 upvotes 4 years ago

Topical application of Eriodictyon angustifolium extract can prevent and reverse age-related beard graying and darken gray hair by increasing melanin production. Sterubin, a component of the extract, also promotes hair pigmentation and protects cells from DNA damage.

community Why is Finasteride seen as “scary” for men, but hormonal birth control is totally normalized for women?

in Finasteride/Dutasteride 757 upvotes 1 year ago

Finasteride is seen as risky for men due to side effects like erectile dysfunction, while hormonal birth control for women is normalized despite its side effects. The discussion points out a double standard influenced by societal and gender norms.

community Is this real chat? Finasteride -> fountain of youth and longevity drug?

559 upvotes 1 year ago

Finasteride is discussed as a hair loss treatment with benefits like reduced prostate enlargement and skin aging, but it is not seen as a "fountain of youth." Users report mixed experiences, including side effects like decreased libido and dry eyes.

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Learn

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learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn Melanogray

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Clinics

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SMP
Chiesen Beauty Acupuncture, Moxibustion & Rumera (Melanin Care)Shizuoka · JP

Experts

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22
Hair System Specialist
Jane Genesi
Marlton, PA, United States

Jane Genesi