The inductive effect of ginsenoside F2 on hair growth by altering the WNT signal pathway in telogen mouse skin
May 2014
in “European Journal of Pharmacology”
TLDR Ginsenoside F2 from ginseng may increase hair growth better than standard treatments by affecting cell growth signals.
In the 2014 study, ginsenoside F2, a component of ginseng, was shown to significantly promote hair growth in telogen-phase mice by modulating the WNT signaling pathway. The substance increased the proliferation of human hair dermal papilla cells and keratinocytes by 30% more than finasteride, a standard hair growth medication. Ginsenoside F2 also upregulated β-catenin and Lef-1 by 140% and 200% respectively, while downregulating DKK-1 by 40%, compared to finasteride. In C57BL/6 mice, F2 treatment led to a 20% higher rate of hair growth promotion than finasteride, with histological analysis showing an increase in hair follicles, epidermal thickness, and follicles in the anagen phase. The study concluded that ginsenoside F2 has potential as a new therapeutic agent for hair growth and anagen induction.
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