The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men

    John K. Amory, Christina Wang, Ronald S. Swerdloff, Bradley D. Anawalt, Alvin M. Matsumoto, William J. Bremner, Susan P. Walker, Lynda J. Haberer, Richard F. Clark
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    TLDR Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.
    A study from 16 years ago found that dutasteride and finasteride, two drugs used for hair loss treatment, can decrease semen volume, sperm concentration, and total sperm count in healthy men, but do not affect sperm motility or morphology. The drugs also lower serum levels of DHT and PSA, but the changes in semen parameters are reversible after stopping the drugs. The study suggests that these drugs should be used with caution in men who desire fertility.
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