Models for Evaluating Teacher Professional Activity

The study assessed the effects of isotretinoin on hirsutism, menstrual cycle, and hormonal response in 76 adolescents with acne vulgaris. It was found that isotretinoin treatment led to changes in adrenal hormone levels, with significant differences in menstrual irregularity and hirsutism rates observed at the third and sixth months of treatment. Free testosterone, total testosterone, and dehydroepiandrosterone sulfate levels increased, while sex hormone-binding globulin levels decreased over the treatment period. These hormonal changes were associated with the development of menstrual irregularity and hirsutism during treatment follow-ups.