37 citations
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January 2013 in “Postepy Dermatologii I Alergologii” This article discusses isotretinoin for severe acne vulgaris, noting its effectiveness but also highlighting significant side effects on skin, mucous membranes, and hair; it reports no new clinical results.
13 citations
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March 2014 in “Cutaneous and Ocular Toxicology” This study found that while isotretinoin lowered levels of female hormones in patients with severe acne, it did not significantly impact ovarian reserve function.
7 citations
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August 2024 in “Journal of Cosmetic Dermatology” This study reported that oral isotretinoin can be an effective and safe treatment for acne vulgaris when used at the appropriate dosage, offering a low-complication option.
June 2026 in “International Journal of Innovative Technologies in Social Science” This review highlights the broad range of adverse effects associated with isotretinoin in acne treatment and examines strategies such as dietary supplementation and adjusted dosing protocols to enhance patient tolerability while maintaining efficacy.
19 citations
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November 2012 in “Journal of Dermatological Treatment” In this study, isotretinoin treatment in women with severe acne increased body weight and triglycerides but did not affect androgens or insulin sensitivity.