Distinct Use of Super-Enhancer Elements Controls Cell Type-Specific CD25 Transcription and Function

    November 2023 in “ Science Immunology ”
    Rosanne Spolski, Peng Li, Vivek Chandra … Warren J. Leonard
    Studysummary This study found that deleting specific super-enhancer regions in mice affects CD25 expression in a cell type-specific manner, leading to autoimmune alopecia in some cases and revealing distinct regulatory mechanisms for constitutive and inducible expression of CD25.
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    Research cited in this study 3

    1. A Transcriptomic Map of Murine and Human Alopecia Areata JCI Insight · 2020
    2. Pioneer Factors Govern Super-Enhancer Dynamics in Stem Cell Plasticity and Lineage Choice Nature · 2015
    3. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014