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research Altered expression of intracellular Toll-like receptors in peripheral blood mononuclear cells from patients with alopecia areata

12 citations , March 2016 in “BBA clinical”

This study found that intracellular Toll-like receptors were significantly up-regulated in peripheral blood mononuclear cells of alopecia areata patients, suggesting a potential role in inflammatory signaling and pathogenesis.

research Ex Vivo Treatment with Allogenic Mesenchymal Stem Cells of a Healthy Donor on Peripheral Blood Mononuclear Cells of Patients with Severe Alopecia Areata: Targeting Dysregulated T Cells and the Acquisition of Immunotolerance

1 citations , October 2022 in “International Journal of Molecular Sciences”

This study suggests that allogenic human mesenchymal stem cell treatments have potential therapeutic effects by inducing immune tolerance and anti-inflammatory effects in severe alopecia areata patients.

research Integrated single-cell chromatin and transcriptomic analyses of peripheral immune cells in patients with alopecia areata

4 citations , July 2025 in “Frontiers in Immunology”

This study explored peripheral blood immune dysregulation in alopecia areata through single-cell analyses, identifying systemic changes linked to disease severity and key signaling roles for monocytes, NK cells, and memory T cells, suggesting potential therapeutic targets.

research Table 1_Integrated single-cell chromatin and transcriptomic analyses of peripheral immune cells in patients with alopecia areata.docx

July 2025 in “Figshare”

This study found that patients with alopecia areata, particularly those with severe cases, exhibit significant systemic immune dysregulation, including altered cell communication networks and epigenetic remodeling in immune cells, suggesting potential pathways for therapeutic targeting.

research 058 Subset analysis of NKG2D+ cells in peripheral blood mononuclear cells

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study analyzed blood samples from individuals with alopecia areata and found that NKG2D+ immune cells, particularly memory-like NK cells, may better correlate with disease activity compared to CD8+ cells, though significant variability among individuals complicates these findings.

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community Why hasn’t anyone made a "DHT sponge" biologic yet???

in Research/Science 45 upvotes 10 months ago

The conversation discusses the potential for developing a biologic "DHT sponge" to neutralize DHT in the bloodstream as a treatment for hair loss, suggesting it could be more targeted and have fewer side effects than current treatments like finasteride and dutasteride. Concerns include the complexity, cost, and potential side effects of such a treatment, as well as skepticism about its feasibility and market interest.

community How come dutasteride doesn't lower allopregnanolone, but finasteride does?

12 upvotes 1 year ago

Finasteride significantly lowers allopregnanolone levels, while dutasteride's effect is less clear and may vary. Some users speculate that dutasteride might be healthier for the brain due to its different inhibition pathways.

community Why do people here trust Kevin Mann?

36 upvotes 6 years ago

Concerns about finasteride's side effects on neurosteroids and brain health, with skepticism towards Kevin Mann's advice. Users discuss using finasteride, minoxidil, and RU58841 for hair loss, with mixed opinions on their safety and effectiveness.

community Finasteride and Eye Problems: You’re Not Going Crazy

in Finasteride/Dutasteride 503 upvotes 1 year ago

Finasteride can cause dry eyes and vision issues due to its impact on the meibomian glands. Users have mixed experiences, with some experiencing eye discomfort and others having no side effects.

community Anyone read oral minoxidil's leaflet?

4 upvotes 1 year ago

Oral minoxidil is discussed, highlighting potential cardiovascular risks at high doses, but users note that lower doses commonly used for hair loss are generally considered safe. Monitoring by doctors is advised, and some users report taking it without issues, comparing its risks to those of common medications like ibuprofen.

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