Splenic Melanosis During Normal Murine C57BL/6 Hair Cycle and After Chemotherapy

July 2013 in “ Acta Biochimica Polonica ”

Dominika Michalczyk‐Wetula, Aleksander Salwiński, Małgorzata Popik, Monika A. Jakubowska, Przemysław M. Płonka

hair cycle catagen phase cyclophosphamide melanin splenic melanosis

Studysummary In this study, researchers found that cyclophosphamide treatment unexpectedly reduced splenic melanin deposition in a murine model, whereas this effect was down-regulated more by the normal and dystrophic catagen phase of the hair cycle.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on ojs.ptbioch.edu.pl →

Discuss this study in the Community →

Research cited in this study

13 / 13 results

research Pathobiology of Chemotherapy-Induced Hair Loss

218 citations , January 2013 in “The Lancet Oncology”

This review discusses the pathobiology of chemotherapy-induced alopecia and highlights challenges in managing it, reporting no new clinical results and emphasizing the need for well-designed preclinical models to develop effective treatments.

research Extradermal Melanin Transfer? Lack of Macroscopic Spleen Melanization in Old C57BL/6 Mice with De-Synchronized Hair Cycle

10 citations , June 2009 in “Acta Biochimica Polonica”

This study found that splenic melanosis in C57BL/6 mice is associated with synchronized skin melanization during hair cycles, but decreases with age.

research Senile Hair Graying: H2O2-Mediated Oxidative Stress Affects Human Hair Color by Blunting Methionine Sulfoxide Repair

217 citations , February 2009 in “The FASEB Journal”

This study found that hydrogen peroxide accumulation and reduced methionine sulfoxide repair play a significant role in the oxidative damage linked to senile hair graying.

research Profiling the Response of Human Hair Follicles to Ultraviolet Radiation

53 citations , January 2009 in “Journal of Investigative Dermatology”

In this study, UVB irradiation of organ-cultured human anagen hair follicles in vitro reduced hair elongation and increased cell death, affecting hair growth and regulatory processes.

research Oral Zinc Sulphate Causes Murine Hair Hypopigmentation And Is A Potent Inhibitor Of Eumelanogenesis In Vivo

30 citations , June 2006 in “British journal of dermatology/British journal of dermatology, Supplement”

In this study, oral zinc sulphate was found to cause hair hypopigmentation and significantly inhibit eumelanogenesis in mice.

research A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice

106 citations , June 2005 in “Journal of Investigative Dermatology”

This study defines classification criteria for hair follicle dystrophy using a mouse model of chemotherapy-induced alopecia, providing tools for standardized hair damage assessment.

research Splenic Eumelanin Differs From Hair Eumelanin in C57BL/6 Mice

38 citations , June 2005 in “Acta Biochimica Polonica”

This study found that spleens of black C57BL/6 mice contain eumelanin, with properties different from skin and hair melanin, and may originate from skin melanin transported by immune cells.

research Hair Follicle Pigmentation: Mechanisms and Factors Influencing Melanin Production

450 citations , January 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

This article reviews follicular melanogenesis, detailing how melanin synthesis and its regulation in hair follicles depend on a complex interplay of cellular and molecular mechanisms, but reports no new clinical findings.

Topical Application of Cyclosporin A Induces Rapid Remodeling of Damaged Anagen Hair Follicles in Cyclophosphamide-Administered Mice

research Topical Application of Cyclosporin A Induces Rapid Remodeling of Damaged Anagen Hair Follicles in Cyclophosphamide-Administered Mice

24 citations , September 2001 in “Journal of Dermatological Science”

This study found that cyclophosphamide-induced hair follicle damage in C3H mice could be remodelled into intact anagen hair follicles with topical cyclosporin A, especially in anagen IV stage follicles.

research Melanogenesis During the Anagen-Catagen-Telogen Transformation of the Murine Hair Cycle

161 citations , June 1994 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that the switch-off of melanogenesis during the hair cycle in C57 BL-6 mice is a gradual and stochastic process starting in mid anagen VI, with specific biochemical markers indicating the transition to catagen.

Chemotherapy-Induced Alopecia in Mice: Induction by Cyclophosphamide, Inhibition by Cyclosporine A, and Modulation by Dexamethasone

research Chemotherapy-Induced Alopecia in Mice: Induction by Cyclophosphamide, Inhibition by Cyclosporine A, and Modulation by Dexamethasone

36 citations , April 1994 in “PubMed”

This study introduces a mouse model of cyclophosphamide-induced alopecia, which effectively replicates human chemotherapy-induced hair loss and can be pharmacologically manipulated to study hair regrowth patterns.

Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth

research Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth

210 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

This review discusses the role of intrinsic skin signals, rather than serum signals, in regulating melanin synthesis and hair pigmentation, but reports no new experimental data.

research Growth of the Hair

521 citations , January 1954 in “Physiological Reviews”

Hair growth is cyclic and influenced mainly by local factors.