Splenic Melanosis During Normal Murine C57BL/6 Hair Cycle and After Chemotherapy

    July 2013 in “ Acta Biochimica Polonica ”
    Dominika Michalczyk‐Wetula, Aleksander Salwiński, Małgorzata Popik, Monika A. Jakubowska, Przemysław M. Płonka
    TLDR Chemotherapy reduces splenic melanin in mice.
    The study investigated the effects of chemotherapy on splenic melanosis using the C57BL/6 murine model. Researchers expected an increase in splenic melanin deposition after chemotherapy but found that cyclophosphamide treatment led to a decrease in splenic melanin. This decrease was abrupt and lasted for at least 5 days post-treatment. A similar reduction in splenic melanization was observed during the normal hair cycle before entering the catagen phase, followed by a gradual increase. The study concluded that cyclophosphamide negatively impacted splenic melanization and the extradermal transfer of ectopic melanin, with the catagen phase being the most significant down-regulator of splenic melanosis.
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