Characterization of Spironolactone and Metabolites Derivatized Using Girard's Reagent P with Mass Spectrometry and Ion Mobility Spectrometry

    May 2024 in “ Rapid Communications in Mass Spectrometry ”
    Stephanie M. Jones, Kaylie I. Kirkwood‐Donelson, Georgia M. Alexander … Alan K. Jarmusch
    Studysummary This study demonstrated that GP derivatization improves mass spectral analysis of spironolactone and its metabolites by reducing in-source fragmentation and enhancing signal clarity, laying the groundwork for future advancements in reaction optimization and quantitative assay development.
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    Research cited in this study 2

    1. Liquid Chromatography-Mass Spectrometry for Simultaneous Determination of Spironolactone and Canrenone in Plasma Samples Brazilian Journal of Pharmaceutical Sciences · 2023
    2. Demographics of Women with Female Pattern Hair Loss and the Effectiveness of Spironolactone Therapy Journal of The American Academy of Dermatology · 2015