SnapshotDx Quiz: March 2016

February 2016 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

Jenny Baker, Mariya Miteva

alopecia areata autoimmune disease CD103+CD8+ resident memory T-cells JAK inhibitors tofacitinib ruxolitinib baricitinib chemokines chemokine receptors inflammation transcriptional patterns AA Xeljanz Jakafi Olumiant

TLDR JAK inhibitors may help treat alopecia areata by reversing hair loss.

The "SnapshotDx Quiz: March 2016" document discussed alopecia areata (AA), an autoimmune disease causing abrupt hair loss, and highlighted findings from a study by Li et al. The study identified CD103+CD8+ resident memory T-cells in active AA biopsies and suggested the potential use of JAK inhibitors for treatment. Small pilot studies and case reports showed that JAK inhibitors like tofacitinib, ruxolitinib, and baricitinib could reverse AA. The study also found increased expression of chemokines and chemokine receptors in active AA bulbs, indicating a role in inflammation and relapse, and abnormal transcriptional patterns in regrown follicles, suggesting a persistent predisposition to AA.

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Research cited in this study

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research Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib

184 citations, February 2015 in “EBioMedicine”

A patient with Alopecia Areata had complete hair regrowth after using the drug baricitinib.

research The Autoimmune Basis of Alopecia Areata: A Comprehensive Review

162 citations, October 2014 in “Autoimmunity reviews”

Alopecia areata is caused by the immune system attacking hair follicles.

research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

701 citations, August 2014 in “Nature medicine”

Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.

research Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis

185 citations, June 2014 in “Journal of Investigative Dermatology”

A man with severe hair loss and skin disease regrew his hair with no side effects after taking tofacitinib.

research Prognostic Factors That Affect the Response to Topical Treatment in Patchy Alopecia Areata

13 citations, November 2012 in “Journal of The European Academy of Dermatology and Venereology”

Certain factors like allergies, nail problems, and hair loss patterns can predict how well someone with patchy hair loss will respond to skin cream treatments.

research Alopecia Areata: An Autoimmune Disease Causing Hair Loss

421 citations, April 2012 in “The New England Journal of Medicine”

Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.

research Lichen Planopilaris: Update on Diagnosis and Treatment

160 citations, March 2009 in “Seminars in Cutaneous Medicine and Surgery”

New insights show Lichen Planopilaris is a rare, scarring hair loss condition, hard to treat, mainly affecting middle-aged women, and significantly impacts mental health.

research Determinants of Marginal Traction Alopecia in African Girls and Women

94 citations, September 2008 in “Journal of the American Academy of Dermatology”

Traction alopecia is more common in African women than girls, especially when traction is applied to chemically relaxed hair; avoiding such hairstyles may reduce the risk.

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SnapshotDx Quiz: March 2016

Research cited in this study

research Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib

research The Autoimmune Basis of Alopecia Areata: A Comprehensive Review

research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

research Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis

research Prognostic Factors That Affect the Response to Topical Treatment in Patchy Alopecia Areata

research Alopecia Areata: An Autoimmune Disease Causing Hair Loss

research Lichen Planopilaris: Update on Diagnosis and Treatment

research Determinants of Marginal Traction Alopecia in African Girls and Women

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