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Comparative Spatial Transcriptomic and Single-Cell Analyses of Human Nail Units and Hair Follicles Show Transcriptional Similarities between the Onychodermis and Follicular Dermal Papilla

research Comparative Spatial Transcriptomic and Single-Cell Analyses of Human Nail Units and Hair Follicles Show Transcriptional Similarities between the Onychodermis and Follicular Dermal Papilla

10 citations, July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Human nails and hair follicles have similar gene activity, especially in the cells that contribute to their growth and development.

research SnapshotDx Quiz: March 2016

February 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

JAK inhibitors may help treat alopecia areata by reversing hair loss.

research Mediator 1 Ablation Induces Enamel-to-Hair Lineage Conversion in Mice Through Enhancer Dynamics

1 citations, July 2023 in “Communications biology”

Removing Mediator 1 from certain mouse cells causes teeth to grow hair instead of enamel.

Reshaped DNA Methylation Cooperating with Homoeolog-Divergent Expression Promotes Improved Root Traits in Synthesized Tetraploid Wheat

research Reshaped DNA Methylation Cooperating with Homoeolog-Divergent Expression Promotes Improved Root Traits in Synthesized Tetraploid Wheat

February 2024 in “New phytologist”

DNA changes in tetraploid wheat improve root growth and nitrogen use.

research PI3K/Akt Signaling Pathway Is Essential for De Novo Hair Follicle Regeneration

30 citations, April 2020 in “Stem Cell Research & Therapy”

PI3K/Akt pathway is crucial for hair growth and regeneration.

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community The Real Cause Of Androgenetic Alopecia

in Research/Science 667 upvotes 1 month ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Testosterone in Reference Range Doesn't Cause Hair Loss

in Research/Science 51 upvotes 9 months ago

Testosterone within the normal range does not significantly contribute to male pattern baldness (MPB); DHT is the main factor that can be controlled. Genetics play a crucial role in hair loss, and treatments like finasteride and dutasteride, which block DHT, can help despite potentially raising testosterone levels.

community Progress: From June 2022 (7 months of min + fin) to now (1 year) — I’ve lost so much density in this period and I have no idea why. I was getting pretty good resultup until that point. Is there anything else I can try? I’ve tried min, fin, tretinoin, micro needling, and castor oil. I feel hopeless.

in Progress Pictures 10 upvotes 1 year ago

The user lost hair density after 7 months of using minoxidil and finasteride and is seeking advice on other treatments after trying tretinoin, microneedling, and castor oil. Suggestions include checking for scalp conditions like eczema or psoriasis, changing minoxidil brands, and questioning hair dryer use and finasteride dosage.

community I want to sacrifice my hair in the name of science

in Chat 12 upvotes 1 year ago

The conversation discusses various theories of hair loss, including DHT sensitivity and genetic factors, with the user willing to use themselves for research due to having a hair loss gene but different hair loss patterns compared to their brothers. Specific treatments were not mentioned in the provided text.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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