SnapshotDx Quiz: December 2018

    Fabrizio Galimberti, Preetha Kamath, Mariya Miteva
    The document discussed a quiz from the Journal of Investigative Dermatology focusing on diagnosing hair and scalp conditions, with the correct diagnosis being Lichen Planopilaris (LPP), a type of cicatricial alopecia leading to irreversible hair loss. It highlighted the immune privilege of the hair follicle bulge, which contains epithelial stem cells (eSC) protected from autoimmune attacks. In LPP, this privilege was compromised, making eSC vulnerable to destruction by CD8+ T cells, with interferon-gamma (IFN-γ) playing a role in this process. The document also explored the epithelial-to-mesenchymal transition (EMT) and the role of peroxisome proliferator-activated receptor (PPAR)-γ in maintaining hair follicle health, suggesting that PPAR-γ modulation could potentially reverse early EMT changes, offering insights into therapeutic approaches for LPP.
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