Skin Alterations as Possible Clinical Markers of Diabetes Mellitus and Metabolic Syndrome

The review explores skin changes linked to diabetes mellitus and metabolic syndrome, including acanthosis nigricans, xeroderma, and diabetic dermopathy, and their potential mechanisms connecting metabolic syndrome with skin diseases like psoriasis, acne vulgaris, and androgenetic alopecia. These skin manifestations can signal insulin resistance and glucose intolerance, while xanthomas may indicate dyslipidemia. Recognizing these correlations is vital for early diagnosis and prevention, providing new therapeutic strategies. Primary care physicians and dermatologists are essential in early detection and treatment, which may lower cardiovascular risks associated with metabolic syndrome.