Skin Alterations as Possible Clinical Markers of Diabetes Mellitus and Metabolic Syndrome

The review highlights the connection between skin changes and metabolic conditions like diabetes mellitus and metabolic syndrome. It discusses how skin manifestations such as acanthosis nigricans, xeroderma, and diabetic dermopathy can indicate insulin resistance and glucose intolerance, while xanthomas and xanthelasmas suggest dyslipidemia. Conditions like psoriasis and hidradenitis suppurativa are linked to metabolic syndrome and obesity, whereas acne, hirsutism, and androgenetic alopecia are signs of hyperandrogenism. Understanding these correlations aids in early diagnosis and prevention, offering insights for new treatments. Primary care physicians, dermatovenerologists, and cosmetologists are crucial for early detection and treatment, potentially reducing cardiovascular risks associated with metabolic syndrome.