SHP099-Containing Multi-Targeting Hydrogel Promotes Rapid Skin Reconstruction Through Modulating a Variety of Cells

The study examines the use of a SHP099-containing multi-targeting hydrogel (Gel-SHP) to enhance wound healing and hair follicle regeneration. Gel-SHP accelerates wound closure and promotes hair follicle regeneration in mice by modulating macrophage differentiation towards the M2 phenotype, reducing inflammation, and enhancing tissue regeneration. It facilitates wound closure through angiogenesis and myofibroblast differentiation, marked by increased alpha-SMA expression, and enhances Caldesmon-1 expression, supporting the formation of the dermal shell around hair follicles. These findings suggest that Gel-SHP could be a promising treatment for improving wound healing and hair regeneration.