Secretome of Hypoxic Mesenchymal Stem Cells Improves Fluconazole-Induced Alopecia in Rats via Immunoregulatory Modulation of IL-15 and IFN-γ

April 2024 in “ Biosaintifika Journal of Biology & Biology Education ”

Carolina Kiwik Rahardja, Sri Priyantini Mulyani, Agung Putra

hypoxic mesenchymal stem cell secretome fluconazole-related alopecia IL-15 IFN-γ alopecia mesenchymal stem cells immune modulation hMSC secretome fluconazole-induced hair loss interleukin-15 interferon gamma

TLDR A gel from stem cells can reduce baldness caused by fluconazole in rats.

The study investigated the effects of a hypoxic mesenchymal stem cell (hMSC) secretome gel on fluconazole-related alopecia (FRA) in 24 male Wistar rats. The hMSC secretome, derived from rat umbilical cords and cultured under hypoxia, was formulated into a gel and applied topically. The study found that the gel significantly reduced IL-15 and IFN-γ mRNA expression and decreased baldness by up to 60%. The most effective formulation contained 20% hMSC secretome. These findings suggest that hMSC secretome gel could be a promising treatment for FRA by modulating immune responses.

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Secretome of Hypoxic Mesenchymal Stem Cells Improves Fluconazole-Induced Alopecia in Rats via Immunoregulatory Modulation of IL-15 and IFN-γ

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