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research Secretome of Hypoxic Mesenchymal Stem Cells Improves Fluconazole-Induced Alopecia in Rats via Immunoregulatory Modulation of IL-15 and IFN-γ

April 2024 in “Biosaintifika Journal of Biology & Biology Education”

In this study, researchers observed that a topical gel containing 20% hypoxia mesenchymal stem cell secretome significantly reduced IL-15 and IFN-γ mRNA expression and baldness by 60% in male Wistar rats with fluconazole-related alopecia.

Effect of Topical Gel Administration of Secretome Hypoxia Mesenchymal Stem Cells on IL-10 and TNF-α Gene Expression: An In Vivo Experimental Study in Male Wistar Rats with Fluconazole-Induced Alopecia

research Effect of Topical Gel Administration of Secretome Hypoxia Mesenchymal Stem Cells (SH-MSCs) on IL-10 and TNF- α Gene Expression (In Vivo Experimental Study in Male Rats of Wistar Strains Model of Fluconazole-Induced Alopecia)

December 2023 in “International journal of multidisciplinary research and analysis”

In this study, topical administration of secretome hypoxia mesenchymal stem cells gel increased IL-10 and decreased TNF-α gene expression in a fluconazole-induced alopecia-like model in rats, with the 40 μL dose having the most significant effect.

research Retinoic Acid Is Not Involved in Fluconazole-Induced Alopecia: Evaluation in a Human Cohort and Rat Model

1 citations , January 2016 in “Open Forum Infectious Diseases”

This study found that fluconazole induced early hair follicle resting phase (telogen effluvium) in rats, without changing retinoic acid levels in rats or human patients, suggesting further investigation into fluconazole's hair loss mechanism is needed.

The Effect of Topical Gel Secretome Hypoxic Mesenchymal Stem Cells on IL-6 and TGF-β Gene Expression in Male Wistar Alopecia-Like Rat Models Induced by Fluconazole

research The Effect of Topical Gel Secretome Hypoxic Mesenchymal Stem Cells (SH-MSCs) on IL-6 and TGF- β Gene Expression (Experimental Study in Male Wistar Alopecia-Like Rat Models Induced by Fluconazole)

December 2023 in “International journal of multidisciplinary research and analysis”

This study suggests that administering SH-MSCs gel might decrease IL-6 expression and increase TGF-β expression in alopecia-like rats, indicating potential for alopecia therapy.

research Culprits of Medication-Induced Telogen Effluvium, Part 1

December 2023 in “Cutis”

This review covers medication-induced telogen effluvium with a focus on systemic retinoids, antifungal agents, and psychotropic medications, and reports no new clinical results.

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Community Join

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community "DHT Itch" and onset Seborrheic Dermatitis

in Research/Science 76 upvotes 2 years ago

The post and conversation discuss the link between DHT (a hormone), scalp itchiness, and hair loss. Some users share their experiences and treatments, including the use of fluconazole, corticosteroids, and ketoconazole shampoo, with one user suspecting minoxidil as a potential cause of their symptoms.

community Starting ketoconzole. How much and How many times a week?

in Ketoconazole 12 upvotes 1 year ago

A user is experiencing severe dandruff and hair loss, considering using ketoconazole shampoo 2% to manage these issues. They seek advice on application frequency and effectiveness, with suggestions to use it 2-3 times a week and to consider other treatments like finasteride for hair loss.

community Folic Acid and hair loss

4 upvotes 7 years ago

A user experienced hair loss due to a folic acid deficiency and saw hair regrowth after taking a folic acid supplement. They advise checking for a folic acid deficiency before spending money on other treatments.

community My experience with fin and my unhealthy obsession with my hair m21

in Update 97 upvotes 1 year ago

Finasteride helped stop hair loss progression and slightly thickened hair, but reduced beard and chest hair growth. The user also uses ketoconazole shampoo for scalp itchiness.

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Learn

5 / 801 results

learn Ketoconazole

antifungal with some anti-androgenic benefits, often used as a shampoo

Can ketoconazole make hair loss worse before it makes it better? Ketoconazole may cause temporary hair shedding before potential improvement in hair growth.
Does ketoconazole really help with hair loss? Ketoconazole may help reduce hair loss by inhibiting DHT and reducing scalp inflammation.
Ketoconazole: Is it safe to use every day or can it damage my hair? Ketoconazole shampoo is labelled for use about two to three times a week, and no published trial has tested daily use for hair loss; dermatology guidance and the product label warn that more frequent use tends to dry and irritate the scalp.

learn Fluocinolone

Can long-term use of Fluocinolone affect the health of hair follicles? There is no long-term human trial measuring what topical fluocinolone does to hair follicles; what is documented is the label's warning about skin atrophy with prolonged use, plus a 2007 mouse study suggesting hair-follicle bulge stem cells do not repair steroid-induced atrophy.
Is Fluocinolone a treatment for hair loss itself or just for calming scalp irritation? Fluocinolone acetonide is a prescription corticosteroid approved for inflammatory skin conditions, not for hair loss; no published human trial has measured hair regrowth with it, so at most it may help indirectly by calming an inflamed scalp.

learn Cetirizine

popular antihistamine showing promise for hair loss as an anti-inflammatory and prostaglandin inhibitor

learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

learn Alopecia Areata

autoimmune disorder causing patchy hair loss

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