Accelerated, Injectable, Self-Healing, Scarless Wound Dressings Using rGO Reinforced Dextran/Chitosan Hydrogels Incorporated with PDA-Loaded Asiaticoside

August 2024 in “ International Journal of Biological Macromolecules ”

Jun Deng, Jingyu Li, Lizhao Yan, Wei Guo, Xiaoyue Ding, Peng Ding, Shuang Liu, Yanfang Sun, Guohua Jiang, Oseweuba Valentine Okoro, Amin Shavandi, Zhizhong Xie, Lihong Fan, Lei Nie

reduced graphene oxide dextran chitosan polydopamine asiaticoside hydrogels nanoparticles wound healing scar formation antibacterial antioxidant rGO PDA AC self-healing dressings injectable dressings

TLDR The hydrogel dressings speed up healing and reduce scarring.

The study presents the development of multifunctional hydrogel dressings using reduced graphene oxide (rGO) reinforced dextran/chitosan hydrogels incorporated with polydopamine (PDA)-loaded asiaticoside (AC). These hydrogels exhibit properties such as injectability, self-healing, tissue adhesion, electrical conductivity, and antibacterial and antioxidant activities. The incorporation of AC@PDA nanoparticles enhances wound healing and reduces scar formation. In vivo tests on full-thickness wounds in rats showed that these hydrogels promote faster healing and minimize scarring compared to untreated wounds, highlighting their potential in advanced wound care solutions.