Efficacy of Scalp Cooling Combined with DHL-HisZnNa Lotion in the Prevention of Chemotherapy-Induced Alopecia in Patients with Breast Cancer

    May 2026 in “ Research Square ”
    Misato Araki, Koshi Matsui, Emi Kanaya … Tsutomu Fujii

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary In this study, the combination of scalp cooling therapy and a scalp lotion containing DHL-HisZnNa demonstrated a 91.3% hair recovery rate among breast cancer patients undergoing certain chemotherapy regimens, with no serious adverse events reported.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 5

    1. Cancer-Related Alopecia Risk And Treatment Current Treatment Options in Oncology · 2025
    2. The Utility of DHL-HisZnNa, a Novel Antioxidant, Against Anticancer Agent-Induced Alopecia in Breast Cancer Patients: A Multicenter Phase II Clinical Trial Breast Cancer Research and Treatment · 2019
    3. Permanent Chemotherapy-Induced Alopecia in Patients with Breast Cancer: A 3-Year Prospective Cohort Study ˜The œoncologist · 2018
    4. The Alpha-Lipoic Acid Derivative Sodium Zinc Dihydrolipoylhistidinate Reduces Chemotherapy-Induced Alopecia in a Rat Model: A Pilot Study Surgery today · 2011
    5. Reduction of Intrafollicular Apoptosis in Chemotherapy-Induced Alopecia by Topical Calcitriol Analogs ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998