The Utility of DHL-HisZnNa, a Novel Antioxidant, Against Anticancer Agent-Induced Alopecia in Breast Cancer Patients: A Multicenter Phase II Clinical Trial

    February 2019 in “ Breast Cancer Research and Treatment ”
    Noriko Sagawa, Shinji Ohno, Takahiro Hiratsuka … Seigo Kitano
    Studysummary This study found that applying a 1% sodium N-(dihydrolipoyl)-l-histidinate zinc complex lotion to the scalp did not prevent chemotherapy-induced alopecia in breast cancer patients, but it may aid recovery.
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    Research cited in this study 9

    1. Permanent Alopecia in Patients with Breast Cancer After Taxane Chemotherapy and Adjuvant Hormonal Therapy: Clinicopathologic Findings in a Cohort of 10 Patients Journal of The American Academy of Dermatology · 2017
    2. Efficacy of Interventions for Prevention of Chemotherapy-Induced Alopecia: A Systematic Review and Meta-Analysis International journal of cancer · 2014
    3. Chemoprevention of Doxorubicin-Induced Alopecia in Mice by Dietary Administration of L-Cystine and Vitamin B6 Archives of Dermatological Research · 2012
    4. Permanent Scalp Alopecia Related to Breast Cancer Chemotherapy by Sequential Fluorouracil/Epirubicin/Cyclophosphamide (FEC) and Docetaxel: A Prospective Study of 20 Patients Annals of Oncology · 2012
    5. Chemotherapy-Induced Alopecia Journal of the American Academy of Dermatology · 2011
    6. The Alpha-Lipoic Acid Derivative Sodium Zinc Dihydrolipoylhistidinate Reduces Chemotherapy-Induced Alopecia in a Rat Model: A Pilot Study Surgery today · 2011
    7. Irreversible And Severe Alopecia Following Docetaxel Or Paclitaxel Cytotoxic Therapy For Breast Cancer British journal of dermatology/British journal of dermatology, Supplement · 2009
    8. Reduction of Intrafollicular Apoptosis in Chemotherapy-Induced Alopecia by Topical Calcitriol Analogs ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    9. A Randomized Trial of Minoxidil in Chemotherapy-Induced Alopecia Journal of The American Academy of Dermatology · 1996