The Utility of DHL-HisZnNa, a Novel Antioxidant, Against Anticancer Agent-Induced Alopecia in Breast Cancer Patients: A Multicenter Phase II Clinical Trial

    February 2019 in “ Breast Cancer Research and Treatment ”
    Noriko Sagawa, Shinji Ohno, Takahiro Hiratsuka, Naoto Kondo, Hiroji Iwata, Hiroko Bando, Tetsuji Ohyama, M. Ishida, Yohei Kono, Kentaro Nakajima, Shinichiro Empuku, Setsuko Nishikawa, Yoshiko Irie, Masafumi Inomata, Seigo Kitano
    TLDR DHL-HisZnNa may help reduce hair loss from chemotherapy, but more research is needed.
    The study evaluated the effectiveness of DHL-HisZnNa, a novel antioxidant, in preventing chemotherapy-induced alopecia in breast cancer patients through a multicenter phase II clinical trial in Japan involving 103 patients. Despite all 101 patients analyzed for safety experiencing grade 2 alopecia, the treatment might have aided in recovery, with a median alopecia duration of 119 days for four chemotherapy courses and 203 days for eight courses. Mild to moderate adverse events occurred in 11 patients, and 53 reported alopecia-related symptoms. While DHL-HisZnNa showed potential in reducing CIA, further studies were needed to confirm its efficacy and safety.
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