Role of Transient Receptor Potential Vanilloid 4 Channel in Skin Physiology and Pathology

June 2020 in “ Sultan Qaboos University medical journal ”

Ammar Boudaka, Mallak Al-Yazeedi, Intisar Al‐Lawati

Transient Receptor Potential Vanilloid 4 TRPV4 keratinocytes melanocytes sensory neurons immune cells skin homeostasis pruritus inflammation carcinogenesis

TLDR TRPV4 channel affects skin health and could be a target for treating skin disorders.

The document reviewed the role of the Transient Receptor Potential Vanilloid 4 (TRPV4) channel in skin physiology and pathology. TRPV4, a non-selective cation channel, responded to temperature and various stimuli and was expressed in multiple organs, including the skin. In the skin, it was found in keratinocytes, melanocytes, sensory neurons, and immune cells, playing roles in skin homeostasis and sensation. Dysfunctional TRPV4 activity was linked to skin conditions like barrier compromise, pruritus, pain, inflammation, and carcinogenesis. The channel's pharmacologically-accessible sites made it a potential therapeutic target for skin disorders. The review summarized TRPV4's physiological and pathophysiological effects in the skin.

View this study on journals.squ.edu.om →

Discuss this study in the Community →

Research cited in this study

5 / 5 results

research TRPV4 Is Expressed in Human Hair Follicles and Inhibits Hair Growth In Vitro

25 citations , December 2018 in “Journal of Investigative Dermatology”

TRPV4 slows hair growth by affecting hair follicle cells.

research Targeting Cutaneous Cannabinoid Signaling in Inflammation: A Highway to Heal?

28 citations , January 2017 in “EBioMedicine”

Enhancing cannabinoid signaling may help treat skin inflammation.

research TRP Channels in Skin Biology and Pathophysiology

124 citations , December 2016 in “Pharmaceuticals”

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

research Localization of Mechanosensitive Channel TRPV4 in Mouse Skin

123 citations , November 2003 in “Neuroscience Letters”

TRPV4 helps sense pressure in mouse skin.

research Epithelial Barrier Function: Assembly and Structural Features of the Cornified Cell Envelope

425 citations , August 2002 in “BioEssays”

The cornified cell envelope forms a protective barrier in skin and hair, using specific proteins and lipids to maintain effectiveness.

Related Community Posts Join

6 / 71 results

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

in Research/Science 2 upvotes 11 months ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 413 upvotes 11 months ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community Physician here AMA – 30M oral Fin 1-1.25 mg daily

in Update 47 upvotes 3 years ago

Hair loss treatments, specifically the use of finasteride, microneedling and potentially oral minoxidil. People discussed their experiences with finasteride, its effects on sexual behaviors, as well as potential solutions such as tadalafil or using other growth factor signal peptides for hope in curing male pattern baldness.

community Testosterone is 1600, would taking low dose anti-androgens be a viable treatment option for people who’s T spikes on DHT-blockers?

in Treatment 45 upvotes 2 years ago

The post and conversation are about the user's high testosterone levels and their worsening hair loss despite trying various treatments. They are considering using low doses of anti-androgens to lower their testosterone levels as a potential solution.

community Study: There is 70x Higher Unconjugated DHT in Feces Compared To Blood Levels in Young Adults - Gut Microbiota Manages DHT Recycling and Metabolism

in Research/Science 196 upvotes 5 months ago

Gut microbiota significantly influences androgen metabolism, impacting hair loss treatments like finasteride. Probiotics, dietary changes, and fecal microbiota transplants may help manage DHT levels and improve hair health.

community Creatine's effect on Hair Loss and DHT

in Research/Science 102 upvotes 1 year ago

A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

Related Research

1 / 1 results

research The Multifaceted Functions of TRPV4 and Calcium Oscillations in Tissue Repair

1 citations , January 2024 in “International journal of molecular sciences”

TRPV4 helps cells repair tissue and reduce scarring by controlling calcium levels.