TLDR RIPK1 inhibitors may help prevent alopecia areata by reducing immune cell activity.
This study explores the role of receptor-interacting serine threonine kinase 1 (RIPK1) in alopecia areata (AA) using a mouse model. It was found that RIPK1 expression is elevated in the skin of AA-affected mice, particularly in dendritic cells and CD8+ T cells. The use of RIPK1 inhibitors, such as Necrostatin-1s and GSK2982772, delayed the onset of AA, reduced the number of immune cells in the skin, and increased hair length in a hair organ culture model. These findings suggest that RIPK1 plays a role in the onset of AA by modulating immune cells, and that RIPK1 inhibitors could potentially prevent AA.
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42 citations,
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23 citations,
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701 citations,
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