Reconsidering Quantification and Mechanistic Inference in Platelet-Rich Plasma Research for Androgenetic Alopecia

The study by Koç Babayiğit et al. provides valuable evidence on the use of platelet-rich plasma (PRP) combined with minoxidil for treating androgenetic alopecia (AGA), highlighting the need for improved methodological approaches. The authors emphasize the importance of integrating advanced imaging technologies to better capture follicular dynamics and differentiate between neogenesis and hypertrophic changes. They also suggest that the observed synergy between PRP and minoxidil may be due to overlapping pathways affecting microvascular remodeling. The study underscores the lack of consensus on PRP dosing and calls for standardized reporting to enhance comparability across studies. Additionally, the authors point out the need for incorporating quality-of-life assessments to align objective improvements with patient perceptions. They advocate for a multicenter, randomized protocol to establish causal relationships and support the routine clinical adoption of PRP treatments.