Role of the Wnt Signaling Pathway in Keratoacanthoma

November 2019 in “ Cancer reports ”

Sarita Joshi, Paula M. De Angelis, Manuela Zucknick, Aasa R. Schjølberg, Solveig Norheim Andersen, O. P. F. Clausen

Wnt signaling pathway β-catenin Lef1 Sox9 Cyclin D1 keratoacanthoma hair follicle cycle immunohistochemistry Ki67 Wnt pathway beta-catenin Lef-1 KA hair cycle IHC

Studysummary This study concluded that the Wnt signaling pathway does not significantly influence human keratoacanthoma development, but the overexpression of Sox9 suggests alternate signaling involvement.

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research Differential Sensitivity of Epidermal Cell Subpopulations to Beta-Catenin-Induced Ectopic Hair Follicle Formation

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In this study, researchers observed that the sebaceous gland niche in mice allows for Wnt-induced hair follicle differentiation, unlike the non-permissive bulge.

research Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors

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This study found that continuous β-catenin signaling in adult mouse epidermis can reprogram hair follicles to form benign tumors, which regress after the signaling is discontinued.

research Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation

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This study found that LEF1/TCF3 is necessary but not sufficient for TOPGAL activation in hair follicle development, indicating complex regulation in the skin.