Preliminary Study on Platelet-Rich Plasma Enhancing Autophagy Level and Promoting Hair Growth in Androgenetic Alopecia Model Mice

This study investigates the role of autophagy in androgenetic alopecia (AGA) and the therapeutic efficacy of platelet-rich plasma (PRP) in promoting hair growth. In AGA model mice, PRP treatment significantly increased hair length and weight, and enhanced autophagy levels, as indicated by increased expression of autophagy-related genes (LC3 and Beclin-1). The study also found that rapamycin, an autophagy activator, produced similar hair growth results to PRP, while the combination of PRP with the autophagy inhibitor 3-MA resulted in reduced hair growth and autophagy marker expression. The findings suggest that impaired autophagy may contribute to AGA, and PRP therapy promotes hair growth by enhancing autophagy.