Preliminary Study on Platelet-Rich Plasma Enhancing Autophagy Level and Promoting Hair Growth in Androgenetic Alopecia Model Mice

This study investigates the role of autophagy in androgenetic alopecia (AGA) and the therapeutic effects of platelet-rich plasma (PRP) on hair growth in AGA model mice. The results show that PRP treatment significantly enhances hair growth by increasing the length and weight of new hair and boosting autophagy levels, as indicated by higher expression of autophagy-related markers LC3 and Beclin-1. The study also finds that rapamycin, an autophagy activator, produces similar hair growth results to PRP, while the combination of PRP with the autophagy inhibitor 3-methyladenine (3-MA) reduces hair growth and autophagy marker expression. The findings suggest that impaired autophagy may contribute to AGA, and PRP therapy promotes hair growth by enhancing autophagy.