TLDR Platelet-rich plasma might help with skin aging, ulcers, and hair loss, but more research is needed to prove its effectiveness and safety.
The 2015 document highlights the use of platelet-rich plasma (PRP) in dermatology for treating skin ulcers, skin aging, and alopecia, but notes the lack of sufficient scientific evidence for its official recognition. It reports mixed results, with some case series and controlled studies showing promise, while a meta-analysis of 9 trials with 325 patients did not show significant healing benefits for skin ulcers. For skin aging, a randomized clinical trial with 100 patients found PRP more effective than hyaluronic acid. In treating alopecia, PRP was shown to improve hair density and a randomized, double-blind trial with 45 patients indicated significant improvement in alopecia areata. The document calls for more robust clinical trials to confirm PRP's efficacy and safety, despite its current consideration as safe due to its autologous nature.
205 citations
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April 2013 in “British Journal of Dermatology” Platelet-rich plasma treatment significantly increased hair regrowth and decreased discomfort in alopecia patients, making it a potentially better and safer treatment option.
88 citations
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December 2012 in “Journal of The European Academy of Dermatology and Venereology” Injecting CD34+ cell-containing platelet-rich plasma into the scalp can improve hair count and thickness in people with pattern hair loss.
270 citations
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March 2012 in “Dermatologic Surgery” Platelet-rich plasma can potentially promote hair growth by stimulating cell growth and increasing certain proteins.
251 citations
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October 2006 in “Plastic and reconstructive surgery/PSEF CD journals” Using platelet plasma growth factors in baldness surgery can increase the number of hair follicles.
370 citations
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September 1999 in “The New England Journal of Medicine” Finasteride and minoxidil are effective for hair loss, but continued research is needed for better treatments.
27 citations
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July 2017 in “Facial Plastic Surgery” Platelet-Rich Plasma (PRP) shows promise for hair growth and skin improvement in aesthetic surgery.
7 citations
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February 2022 in “Frontiers in Medicine” Using microneedling with platelet-rich plasma is more effective and just as safe as microneedling alone for treating acne scars.
10 citations
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October 2015 in “Medicina Clínica (english Edition)” Recombinant human epidermal growth factor is versatile, effective, and safe for long-term skin and mucosal treatments.
January 2019 in “Springer eBooks” Platelet-rich plasma therapy may have benefits and is generally safe, but more research is needed to confirm its effectiveness and safety.
17 citations
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November 2021 in “Journal of Cosmetic Dermatology” Combination therapies for androgenetic alopecia work best but can have significant side effects and costs.