Inhibitory Respiratory Responses to Progesterone and Allopregnanolone in Newborn Rats Chronically Treated with Caffeine

October 2015 in “ The Journal of Physiology ”

NagaPraveena Uppari, Vincent Joseph, Aïda Bairam

progesterone allopregnanolone caffeine GABA A receptors GABAergic inhibition

TLDR Combining progesterone with caffeine worsens breathing issues in newborns.

The study investigated the effects of combining progesterone with caffeine treatment in newborn rats to address persistent apnoea, a common issue in preterm neonates. Contrary to expectations, the administration of progesterone in caffeine-treated rats inhibited breathing and increased apnoea frequency. This was attributed to the conversion of progesterone to allopregnanolone, which modulates GABAA receptors and enhances GABAergic inhibition. The study concluded that combining progesterone with chronic caffeine therapy is not advisable for treating persistent apnoea in preterm neonates unless the effects of allopregnanolone can be mitigated.

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Inhibitory Respiratory Responses to Progesterone and Allopregnanolone in Newborn Rats Chronically Treated with Caffeine

Research cited in this study

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