Polycystic Ovarian Syndrome: Exploring Hypertension and Cardiometabolic Implications

    October 2024 in “ Cureus ”
    Gabriela D Briceño Silva, Karem D Thomas Garcia, Hrachya Ajamyan, Pallavi Shekhawat, L Rodriguez, Ahmad Hammoud, Maria de Jesus Avalos Zapata, Natalia Flores Hernandez, Hilda M Rayon Rayon
    TLDR PCOS may increase the risk of high blood pressure and heart issues.
    This review explores the relationship between polycystic ovarian syndrome (PCOS) and hypertension (HTN), emphasizing the cardiometabolic implications of PCOS, which is characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology. These factors contribute to a complex metabolic profile, including insulin resistance, obesity, and dyslipidemia, which collectively increase the risk of HTN. Emerging research suggests that hyperandrogenism in PCOS may influence the renin-angiotensin system, raising blood pressure, while insulin resistance exacerbates HTN through sympathetic nervous system activity and endothelial dysfunction. Although a direct link between PCOS and HTN is not yet established, the review highlights the need for further research to understand these mechanisms and improve management strategies for reducing cardiovascular risks in women with PCOS.
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