Poloxamer Thermosensitive Hydrogels Loaded With hFGF2-Linked Camelina Lipid Droplets Accelerate Skin Regeneration In Deep Second-Degree Burns

October 2022 in “ International Journal of Molecular Sciences ”

Yuan Zhang, Wan-ying He, Shuhan Zhang, Xingli Hu, Siming Sun, , Jie Kong, Hongxiang Liu, Haiyan Li, Xin Liu, Yan Cheng

thermosensitive poloxamer hydrogels hFGF2 Camelina lipid droplets skin regeneration collagen alignment granulation tissue formation vascularization

Studysummary This study found that CLD-hFGF2 hydrogels improved healing in deep second-degree burn wounds more effectively than hydrogels alone or direct administration of CLD-hFGF2. Our plain-language summary of this paper — not a Tressless recommendation.

The study explored the use of thermosensitive poloxamer hydrogels loaded with hFGF2-linked Camelina lipid droplets (CLD-hFGF2) to enhance skin regeneration in deep second-degree burns. These hydrogels provided a controlled release of hFGF2, promoting cell proliferation and migration, and significantly improved wound healing in vivo on Balb/c mice, achieving 69% healing by day 5 and 90% by day 8. The hydrogels facilitated enhanced collagen alignment, granulation tissue formation, and vascularization, suggesting a promising treatment for burn wound healing. The study involved 30 mice for in vivo tests and highlighted the potential of this delivery system in improving burn treatment outcomes.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

Skin-Permeable Liposome Improved Stability and Permeability of bFGF Against Skin of Mice With Deep Second-Degree Scald to Promote Hair Follicle Neogenesis Through Inhibition of Scar Formation

research Skin-Permeable Liposome Improved Stability and Permeability of bFGF Against Skin of Mice With Deep Second-Degree Scald to Promote Hair Follicle Neogenesis Through Inhibition of Scar Formation

26 citations , September 2018 in “Colloids and Surfaces B: Biointerfaces”

This study reported that a novel liposomal formulation, SP-bFGF-SF-LIP, enhanced bFGF stability and skin permeability, significantly improving hair follicle recovery and wound healing in a mouse model.

Oil Body-Bound Oleosin-rhFGF-10: A Novel Drug Delivery System That Improves Skin Penetration to Accelerate Wound Healing and Hair Growth in Mice

research Oil Body-Bound Oleosin-rhFGF-10: A Novel Drug Delivery System That Improves Skin Penetration to Accelerate Wound Healing and Hair Growth in Mice

11 citations , October 2017 in “International Journal of Molecular Sciences”

In this study, oil body-bound oleosin-rhFGF-10 was more efficiently absorbed through the skin and enhanced wound healing and hair growth in mice, compared to prokaryotically-expressed rhFGF-10.

research Expression of Bioactive Recombinant Human Fibroblast Growth Factor 10 in Carthamus Tinctorius L. Seeds

20 citations , September 2015 in “Protein expression and purification”

This study demonstrated that safflower seeds can be engineered to express oleosin-FGF10, which showed a dose-dependent effect on cellular proliferation, potentially facilitating scalable protein production.