TLDR The data set helps improve predictions of how substances are absorbed through pig skin.
The document presented a detailed repository of anatomical and physiological parameters of porcine skin to aid in the parametrization of the Multi-phase Multi-layer Mechanistic Dermal Absorption (MPML MechDermA) Model within the Simcyp Simulator. This physiologically based pharmacokinetic (PBPK) model aimed to improve the accuracy of dermal absorption predictions by accounting for the specific physiology and geometry of skin. The database included 14 parameters such as skin surface pH, stratum corneum layers, and hair follicle characteristics, which could be used to enhance interspecies extrapolation and predict dermatokinetic properties in in vitro permeation testing (IVPT) experiments.
149 citations
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September 2017 in “Pharmaceutics” Pig skin is a good substitute for human skin to measure drug absorption, but differences in skin structure and enzymes across species must be considered.
353 citations
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November 2014 in “Molecular immunology” Porcine skin is very similar to human skin, making it a useful model for research.
38 citations
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June 2018 in “Archives of Toxicology” Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.
5 citations
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May 2020 in “Pharmaceutical Research” Heat and chemicals improve finasteride delivery to scalp and hair follicles, potentially enhancing treatment for hair loss.
10 citations
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April 2016 in “Research and reports in transdermal drug delivery” Transfollicular drug delivery is promising but needs more research to improve and understand it better.
1 citations
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February 2023 in “Applied sciences” The new topical growth hormone formula has high skin penetration and bioavailability.
122 citations
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April 2011 in “European Journal of Pharmaceutics and Biopharmaceutics” Particles around 100 nm can penetrate and stay in hair follicles without passing through healthy skin, making them safe for use in topical products and useful for targeted drug delivery.
