An Open-Access Data Set of Pig Skin Anatomy and Physiology for Modeling Purposes
January 2022
in “
Database
”
TLDR The data set helps improve predictions of how substances are absorbed through pig skin.
The document presented a detailed database of porcine skin anatomical and physiological parameters to aid in the development of physiologically based pharmacokinetic (PBPK) models, particularly the Multi-phase Multi-layer Mechanistic Dermal Absorption (MPML MechDermA) Model. It included 14 parameters such as skin surface pH, stratum corneum thickness, and hair follicle density, essential for modeling dermal absorption and facilitating interspecies extrapolation. Data were sourced from 49 publications to improve the accuracy of PBPK models and predict dermatokinetic properties in in vitro permeation testing (IVPT) experiments, despite some limitations due to inconsistencies in nomenclature and methods.
