Author Response: Spatiotemporal Dynamics of PIEZO1 Localization Controls Keratinocyte Migration During Wound Healing

The study demonstrated that the ion channel PIEZO1 significantly influenced keratinocyte migration and wound healing. Researchers used genetically engineered mice and in vitro scratch assays to show that mice and keratinocytes lacking PIEZO1 healed wounds faster, while those with increased PIEZO1 activity or treated with the PIEZO1 agonist Yoda1 healed more slowly. PIEZO1 was found to localize at the rear of migrating cells, affecting cell polarization and migration direction. These findings suggested that PIEZO1 could be a potential target for improving wound healing, though further research was needed to explore possible side effects.