Polycystic Ovarian Syndrome: Exploring Hypertension and Cardiometabolic Implications

October 2024 in “ Cureus ”

Gabriela D Briceño Silva, Karem D Thomas Garcia, Hrachya Ajamyan, Pallavi Shekhawat, L Rodriguez, Ahmad Hammoud, Maria de Jesus Avalos Zapata, Natalia Flores Hernandez, Hilda M Rayon Rayon

polycystic ovarian syndrome PCOS hyperandrogenism insulin resistance dyslipidemia renin-angiotensin system endothelial dysfunction

Studysummary This review discusses the association between polycystic ovarian syndrome and hypertension, highlighting evidence of metabolic factors influencing this potential link and stressing the need for further research in this area. Our plain-language summary of this paper — not a Tressless recommendation.

This review explores the relationship between polycystic ovarian syndrome (PCOS) and hypertension (HTN), emphasizing the cardiometabolic implications of PCOS, which is characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology. These factors contribute to a complex metabolic profile, including insulin resistance, obesity, and dyslipidemia, which collectively increase the risk of HTN. Emerging research suggests that hyperandrogenism in PCOS may influence the renin-angiotensin system, raising blood pressure, while insulin resistance exacerbates HTN through sympathetic nervous system activity and endothelial dysfunction. Although a direct link between PCOS and HTN is not yet established, the review highlights the need for further research to understand these mechanisms and improve management strategies for reducing cardiovascular risks in women with PCOS.

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Research cited in this study

14 / 14 results

Recommendations From The 2023 International Evidence-Based Guideline For The Assessment And Management Of Polycystic Ovary Syndrome

research Recommendations From The 2023 International Evidence-Based Guideline For The Assessment And Management Of Polycystic Ovary Syndrome

8 citations , August 2023 in “The Journal of Clinical Endocrinology and Metabolism”

This study provided updated international guidelines for assessing and managing polycystic ovary syndrome, emphasizing evidence-based recommendations and acknowledging the low to moderate quality of existing evidence.

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14 citations , March 2022 in “Clinical Endocrinology”

This review outlines a diagnostic approach for identifying non-PCOS pathology in women with androgen excess, emphasizing the importance of clinical history and biochemical phenotyping but reports no new clinical results.

Large-Scale Genome-Wide Meta-Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria

research Large-Scale Genome-Wide Meta-Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria

308 citations , December 2018 in “PLOS Genetics”

This study identified three novel genetic loci associated with PCOS and found similar genetic architecture across different diagnostic criteria, with evidence suggesting genetic links between PCOS and various metabolic and psychological traits.

research Association Between Insulin Resistance and Cardiovascular Risk Factors in Polycystic Ovary Syndrome Patients

15 citations , April 2018 in “Revista Brasileira de Ginecologia e Obstetrícia”

In this study of women with polycystic ovary syndrome, insulin resistance was associated with obesity, waist circumference, lipid accumulation, and hypertension, with no significant difference in prevalence between different diagnostic methods.

research The Prevalence and Phenotypic Features of Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

767 citations , September 2016 in “Human Reproduction”

This review analyzes the reported prevalence of polycystic ovary syndrome (PCOS) based on different diagnostic criteria but does not provide new clinical results.

research Endocrine and Metabolic Characteristics in Polycystic Ovary Syndrome

53 citations , April 2016 in “PubMed”

This review discusses the relationship between PCOS and hirsutism, exploring inflammatory markers and treatment options, and concludes that combining metformin with OCP may benefit both normal weight and obese PCOS patients.

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222 citations , January 2014 in “International journal of reproductive medicine”

This paper reviews the complex pathophysiology of polycystic ovary syndrome, exploring how hormonal and metabolic disturbances contribute to its symptoms and related health risks, but it presents no new findings.

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12 citations , March 2013 in “Gynecological Endocrinology”

This study found that women with PCOS had significantly higher angiotensin converting enzyme activity and insulin resistance compared to controls, suggesting a correlation between these factors.

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27 citations , January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

This article explores the endocrine functions involved in the pathogenesis of polycystic ovarian syndrome and discusses approaches for diagnosing and managing the condition, with no new clinical results reported.

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60 citations , May 2011 in “Endocrinology and Metabolism Clinics of North America”

This article discusses the association between hypertension and polycystic ovary syndrome, highlighting the need for managing related risk factors, but reports no new clinical results.

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991 citations , January 2011 in “Nature Reviews Endocrinology”

This paper reviews the diagnostic criteria, associated morbidities, and possible evolutionary advantages of polycystic ovary syndrome, but does not report any new findings.

research Visually Scoring Hirsutism

288 citations , June 2009 in “Human reproduction update”

This review examines various methods for assessing hair growth in women, highlighting the usefulness of the mFG visual scoring method for diagnosing hirsutism despite its limitations.

research Relationship Between Androgen Levels and Blood Pressure in Young Women With Polycystic Ovary Syndrome

166 citations , March 2007 in “Hypertension”

In this study, hyperandrogenemia in young women with polycystic ovary syndrome was linked to higher blood pressure, independent of factors like age, insulin resistance, obesity, or dyslipidemia.

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4025 citations , December 2003 in “Human Reproduction”

This review discusses the evolution of diagnostic criteria for polycystic ovary syndrome and emphasizes its association with various metabolic and cardiovascular risks, but it provides no new research findings.