The Parathyroid Hormone Second Receptor PTH2R and Its Ligand Tuberoinfundibular Peptide of 39 Residues TIP39 Regulate Intracellular Calcium and Influence Keratinocyte Differentiation

March 2016 in “ Journal of Investigative Dermatology ”

Emi Sato, Jun Muto, Ling‐juan Zhang, Christopher A. Adase, James Sanford, Toshiya Takahashi, Teruaki Nakatsuji, Ted B. Usdin, Richard L. Gallo

parathyroid hormone second receptor PTH2R tuberoinfundibular peptide of 39 residues TIP39 keratinocyte differentiation intracellular calcium keratin-14 involucrin epidermal thickness calcium homeostasis skin biology parathyroid hormone receptor calcium regulation skin development

Studysummary This study suggests that TIP39 and its receptor PTH2R, identified in human epidermis, may play a role in keratinocyte function and influence skin differentiation.

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The study investigated the role of the parathyroid hormone second receptor (PTH2R) and its ligand, tuberoinfundibular peptide of 39 residues (TIP39), in skin biology, focusing on keratinocyte differentiation and calcium homeostasis. TIP39 and PTH2R were found in human and mouse skin, with TIP39 increasing intracellular calcium levels in keratinocytes, promoting differentiation. This was evidenced by decreased keratin-14 and increased involucrin expression. PTH2R−/− mice showed increased epidermal thickness, suggesting TIP39 and PTH2R's role in regulating keratinocyte function and skin development. The study highlighted TIP39's potential impact on calcium transport and genetic skin disorders, emphasizing the need for further research on PTH-related genes in skin function.

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