Evaluation of Total Oxidant and Total Antioxidant Status in Patients with Acne Vulgaris

March 2022 in “ Osmangazi tıp dergisi ”

Ersoy ACER, Hilal KAYA ERDOGAN, Evin Kocatürk, Esra AĞAOĞLU, Nurhan SARACOGLU, Muzaffer Bilgin

acne vulgaris oxidative stress total oxidant status total antioxidant status oxidative stress index antioxidant agents acne TOS TAS OSI

TLDR Acne patients have higher levels of oxidative stress, but it's not clear if it causes or results from acne; antioxidants might help treat acne.

The study involved 32 acne patients and 35 healthy controls, investigating the role of oxidative stress in acne. It was found that both total oxidant status (TOS) and total antioxidant status (TAS) were significantly higher in acne patients, as was the oxidative stress index (OSI). However, these measures were not correlated with disease duration or Global Acne Grading System scores. The study concluded that oxidative stress may be involved in acne pathogenesis, but it's unclear whether it's a cause or a result of acne. Further research is needed, particularly comparing mild to moderate and severe acne patients. The study also suggested that antioxidant agents could be beneficial in acne treatment.

View this study on dergipark.org.tr →

Discuss this study in the Community →

Related Community Posts Join

6 / 581 results

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 65 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Kintor Pharma Announced Successful Dosing of the First Patient for Acne Vulgaris Phase II Clinical Trial of KX-826

in Research/Science 12 upvotes 2 years ago

Kintor Pharma successfully dosed the first patient in a Phase II trial for KX-826 for acne vulgaris. Users are more interested in results for male pattern baldness (MPB).

community DHT Itch is real. The connection between Acne and Male Pattern Baldness shows this

in Research/Science 64 upvotes 1 year ago

The conversation discusses the link between seborrheic dermatitis, acne, and male pattern baldness, suggesting that DHT may cause both skin conditions and hair loss. Treatments mentioned include RU58841, finasteride, dutasteride, minoxidil, Nizoral shampoo, and other topical anti-androgens.

community Kintor Has Completed Enrollment in Phase II Clinical Trial of KX-826 (Pyrilutamide) for Treatment of Male AGA Patients in the US

in Update 23 upvotes 2 years ago

KX-826 (Pyrilutamide) being tested in the US for hair loss treatment and that they have found enough people to participate in phase II clinical trials. Other treatments discussed are Minoxidil, finasteride, and RU58841.

community Finally Scalp Folliculitis-Free after 2 Decades of Suffering

in Treatment 61 upvotes 1 month ago

A 37-year-old male resolved scalp folliculitis by adopting a low-histamine diet and taking Vitamin A, Zinc, and Fish Oil, leading to better skin health and thicker hair. He warns about the potential toxicity of excessive Vitamin A intake.

Similar Research

5 / 1000+ results

research Antioxidants in Dermatology

86 citations, June 2017 in “Anais Brasileiros de Dermatologia”

Antioxidants can benefit skin health but should be used carefully to avoid negative effects.

research Oxidative Stress in Alopecia Areata: A Case-Control Study

62 citations, July 2013 in “American Journal of Clinical Dermatology”

Alopecia areata patients have higher oxidative stress and lower antioxidant levels.

research Ischemia-Modified Albumin: A Potential New Marker of Oxidative Stress in Dermatological Diseases

6 citations, May 2022 in “Medicina-lithuania”

IMA may indicate oxidative stress in skin and hair disorders, but more research is needed.

research Oxidative Stress and Autoimmune Skin Disease

73 citations, January 2013 in “European journal of dermatology/EJD. European journal of dermatology”

Antioxidants may help fight oxidative stress linked to autoimmune skin diseases.

Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza Sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances

research Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza Sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances

7 citations, January 2022 in “Plants”

Rice husk and bran extracts from the Bue Bang 3 CMU variety can potentially treat hair loss due to their antioxidant, anti-inflammatory, and anti-androgenic properties.