Use of Oral Isotretinoin in the Treatment of Frontal Fibrosing Alopecia: Case Series

September 2021 in “ Revista Interdisciplinar em Saúde ”

Neuza Caroline Suassuna Araújo, Lívio e Vasconcelos do Egypto

isotretinoína frontal fibrosing alopecia chronic lymphocytic primary alopecia hair loss alopecia Accutane FFA

TLDR Oral isotretinoína effectively stabilizes frontal fibrosing alopecia.

The study evaluated the therapeutic effects of oral isotretinoína in patients diagnosed with frontal fibrosing alopecia (FFA), a chronic lymphocytic primary alopecia. Through a descriptive observational study involving patient interviews and data collection, the research found that oral isotretinoína treatment effectively stabilized alopecia. This stabilization is significant as hair loss in FFA patients often impacts their femininity and self-esteem. The findings suggest that isotretinoína could be a beneficial treatment option for FFA, aiding healthcare professionals in managing this condition.

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Research cited in this study

7 / 7 results

research Frontal Fibrosing Alopecia: An Update on Pathogenesis, Diagnosis, and Treatment

61 citations, January 2019 in “American Journal of Clinical Dermatology”

The cause of Frontal Fibrosing Alopecia is unclear, diagnosis involves clinical evaluation and various treatments exist, but their effectiveness is uncertain.

research Frontal Fibrosing Alopecia: Clinical and Prognostic Classification

74 citations, April 2017 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Researchers found three patterns of Frontal fibrosing alopecia, with Pattern III having the best prognosis after treatment.

research Frontal Fibrosing Alopecia: A Retrospective Clinical Review of 62 Patients with Treatment Outcome and Long-Term Follow-Up

102 citations, April 2014 in “International Journal of Dermatology”

The treatment helped reduce symptoms and stabilize the hairline in most patients with Frontal Fibrosing Alopecia, but hair regrowth was limited.

research Frontal Fibrosing Alopecia: A Multicenter Review of 355 Patients

5 citations, March 2014 in “Journal of The American Academy of Dermatology”

The study suggests hormonal factors may play a role in Frontal Fibrosing Alopecia and that treatments like oral antiandrogens and steroids could be beneficial.

research Frontal Fibrosing Alopecia: A Retrospective Review of 19 Patients Seen at Duke University

98 citations, February 2013 in “Journal of The American Academy of Dermatology”

Dutasteride may help stabilize Frontal Fibrosing Alopecia, but more research is needed.

research Frontal Fibrosing Alopecia: A Review of 60 Cases

166 citations, April 2012 in “Journal of The American Academy of Dermatology”

Mostly postmenopausal Caucasian women get Frontal Fibrosing Alopecia, which often includes eyebrow loss and has limited treatment success.

research Treatment of Postmenopausal Frontal Fibrosing Alopecia with Oral Dutasteride

64 citations, June 2009 in “Journal of The American Academy of Dermatology”

Oral dutasteride can potentially treat frontal fibrosing alopecia in postmenopausal women, with some patients showing disease arrest and hair regrowth.

Related Community Posts Join

6 / 36 results

community Diffuse hair loss and scalp biopsies

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Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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The post discusses the theory that persistent dandruff in areas prone to hair loss could be a sign of hair follicles dying due to DHT, indicating balding. The responses vary, with some users noting improvements in dandruff and hair loss with treatments like Dutasteride, while others experienced hair loss without dandruff.

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community Isotretinoin and Tretinoin difference

in Product 2 upvotes 1 month ago

Isotretinoin and tretinoin are different; isotretinoin can cause hair loss and has more side effects. Tretinoin may affect minoxidil absorption, and users suggest waiting before applying minoxidil.

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 1 year ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

community Oral min and Isotretinoin (accutane) to respond

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Oral minoxidil combined with isotretinoin may improve hair loss treatment effectiveness. Tretinoin is known to increase the absorption of topical minoxidil.

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