TLDR Oral dutasteride is effective and safe for treating frontal fibrosing alopecia.
Oral dutasteride is recommended as a first-line treatment for frontal fibrosing alopecia (FFA) due to its effectiveness in stabilizing the condition, as demonstrated in a systematic review and meta-analysis involving 366 patients, where 62.8% achieved stabilization. Despite the lack of double-blind randomized controlled trials, dutasteride shows the highest level of evidence among available treatments. Its potential mechanisms include antifibrotic properties, increased tissue oestradiol levels, and immunomodulatory effects. The treatment is considered safe for off-label use and can be combined with other therapies if needed.
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July 2022 in “Frontiers in Pharmacology” Dutasteride may help protect neurons and reduce inflammation in Parkinson's disease.
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March 2019 in “Nature Communications” Frontal fibrosing alopecia is linked to four genetic areas, especially the HLA-B*07:02 allele.
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February 2014 in “Journal of The American Academy of Dermatology” Most patients with frontal fibrosing alopecia are postmenopausal women, and treatments like finasteride and dutasteride can improve or stabilize the condition.
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January 2024 in “Journal of personalized medicine” Hormonal imbalances during menopause may significantly contribute to Frontal Fibrosing Alopecia.
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January 2019 in “American Journal of Clinical Dermatology” The cause of Frontal Fibrosing Alopecia is unclear, diagnosis involves clinical evaluation and various treatments exist, but their effectiveness is uncertain.
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July 2023 in “Journal of Clinical Medicine” Different causes of beard hair loss have various treatments, including medications, lifestyle changes, and procedures to stimulate hair growth.
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April 2022 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” The document concludes that more research is needed to find effective treatments for Lichen planopilaris and Frontal fibrosing alopecia.
August 2025 in “Drug Design Development and Therapy” Current treatments for androgenetic alopecia are complex and promising, but more research is needed.
