Oral Dutasteride as a First-Line Treatment for Frontal Fibrosing Alopecia

The article discusses the use of oral dutasteride as a first-line treatment for frontal fibrosing alopecia (FFA), emphasizing its potential to halt disease progression and improve quality of life despite the lack of high-quality clinical trials. The authors acknowledge the uncertainties in FFA management and propose a therapeutic algorithm that includes oral dutasteride, anti-inflammatory agents, and aesthetic interventions. They highlight the empirical evidence supporting dutasteride's efficacy and safety, particularly in women without reproductive desire, and suggest that future clinical studies should focus on stabilizing the hairline over 1-2 years. The article concludes that while scientific evidence is not yet overwhelming, oral dutasteride remains a viable first-line option in combination with other treatments.