Oral Dutasteride as a First-Line Treatment for Frontal Fibrosing Alopecia

    February 2025 in “ Journal of the European Academy of Dermatology and Venereology ”
    Sergio Vañó‐Galván, Cristina Pindado‐­Ortega, David Saceda‐Corralo
    TLDR Oral dutasteride is a recommended first treatment for frontal fibrosing alopecia.
    The article discusses the use of oral dutasteride as a first-line treatment for frontal fibrosing alopecia (FFA), emphasizing its potential to halt disease progression and improve quality of life despite the lack of high-quality clinical trials. The authors acknowledge the uncertainties in FFA management and propose a therapeutic algorithm that includes oral dutasteride, anti-inflammatory agents, and aesthetic interventions. They highlight the empirical evidence supporting dutasteride's efficacy and safety, particularly in women without reproductive desire, and suggest that future clinical studies should focus on stabilizing the hairline over 1-2 years. The article concludes that while scientific evidence is not yet overwhelming, oral dutasteride remains a viable first-line option in combination with other treatments.
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      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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      The user experienced hair loss despite using Fin and Min for 12 years and switched to Dutasteride, RU58841, and Keto scalp serum, but shedding and itch persist. They are considering increasing Dutasteride to 2.5mg and questioning the necessity of a scalp biopsy, with mixed opinions on its usefulness.

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