Effect of Oleuropein on mRNA and Protein Expression of Growth Factors in C57BL/6N Mouse Skin Tissue

    December 2015 in “ OPAL (Open@LaTrobe) (La Trobe University) ”
    Tao Tong, Kim Nahyun, Taesun Park
    TLDR Oleuropein increases IGF-1 levels in mouse skin.
    The study investigated the effect of oleuropein on the expression of growth factors in C57BL/6N mouse skin tissue, focusing on mRNA and protein levels of IGF-1, HGF, VEGF, and KGF. Using RT-PCR, ELISA, and immunohistochemical analysis, the researchers found that oleuropein influenced the expression of these growth factors, with significant changes noted in IGF-1 levels. The results were based on experiments with 8 mice, and statistical significance was determined using one-way ANOVA and Tukey's test, with p-values indicating varying levels of significance.
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