Impaired Keratinocyte Proliferative And Clonogenic Potential In Transgenic Mice Overexpressing 14-3-3σ In The Epidermis

    June 2011 in “ Journal of Investigative Dermatology ”
    Francesca Cianfarani, Silvia Bernardini, Naomi De Luca … Teresa Odorisio
    Studysummary This study found that overexpressing the 14-3-3σ protein in transgenic mice reduced keratinocyte proliferation and migration, leading to thinner epidermis and fewer hair follicles due to IGF-1 pathway inhibition.
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    Research cited in this study 3

    1. Epidermal Stem Cell Diversity and Quiescence EMBO molecular medicine · 2009
    2. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    3. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003

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