Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia Through Overgrowth of Lactobacillus Murinus in Mice

    August 2017 in “ Cell Reports ”
    Akira Hayashi, Yohei Mikami, Kentaro Miyamoto … Takanori Kanai
    Studysummary This study found that antibiotic-induced gut dysbiosis, particularly overgrowth of Lactobacillus murinus, can lead to hair loss in mice by depleting biotin.
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    Research cited in this study 8

    1. Diffuse Hair Loss in an Adult Female: Approach to Diagnosis and Management Indian Journal of Dermatology, Venereology and Leprology · 2009
    2. Biotin And Biotinidase Deficiency Expert Review of Endocrinology & Metabolism · 2008
    3. Hair Loss Pattern Due to Chemotherapy-Induced Anagen Effluvium: A Cross-Sectional Observation Dermatology · 2007
    4. Transport of Biotin in Human Keratinocytes Journal of Investigative Dermatology · 2003
    5. Telogen Effluvium: Causes, Diagnosis, and Treatment Clinical and Experimental Dermatology · 2002
    6. Effect of Primary Biotin Deficiency on the Skin of Germ-Free and Conventional Mice Fed a Purified Biotin-Deficient Diet Without Supplementation with Egg White Journal of Clinical Biochemistry and Nutrition · 1997
    7. Biotin Deficiency in a Patient with Short Bowel Syndrome During Home Parenteral Nutrition Journal of Parenteral and Enteral Nutrition · 1984
    8. Biotin-Responsive Alopecia and Developmental Regression Lancet · 1979

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