ST14 Interacts With TMEFF1 and Is a Predictor of Poor Prognosis in Ovarian Cancer

    March 2024 in “ BMC cancer ”
    Xin Nie, Lingling Gao, Mingjun Zheng … Bei Lin
    Studysummary This study reports that high expression of proteins ST14 and TMEFF1 in ovarian cancer correlates with higher tumor malignancy and worse prognosis, and reveals an interaction where ST14 regulates TMEFF1 to promote cancer cell proliferation, migration, and invasion.
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    Research cited in this study 4

    1. A Disease-Causing Novel Missense Mutation in the ST14 Gene Underlies Autosomal Recessive Ichthyosis with Hypotrichosis Syndrome in a Consanguineous Family European journal of dermatology/EJD. European journal of dermatology · 2018
    2. The Harmonies Played by TGF-β in Stem Cell Biology Cell Stem Cell · 2012
    3. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    4. Epithelial Integrity Is Maintained by a Matriptase-Dependent Proteolytic Pathway ˜The œAmerican journal of pathology · 2009