A New Horizon in Facial Plastic Surgery: Skin Tissue Engineering and Stem Cell Therapy—Reality or Dream?

Nine years ago, the paper discussed the advancements and challenges in facial skin replacement techniques like allograft and autograft skin transplantation, particularly for burn or injury victims. Despite progress in transplantation, tissue engineering, and stem cell therapies, issues like the lack of hair follicles and sweat glands in cultured skin grafts persisted. The authors proposed that stem cells, due to their self-renewal and differentiation potential, could potentially reconstruct these missing structures within a wound. This insight could aid in the development of new therapies to address issues in facial wound healing.