A New Horizon in Facial Plastic Surgery: Skin Tissue Engineering and Stem Cell Therapy—Reality or Dream?

    Seied Omid Keyhan, Seifollah Hemmat, Mohammad Ali Asayesh, Peyman Mehriar, Arash Khojasteh
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    Studysummary This review discusses advancements and challenges in laboratory-based tissue-expansion and transplantation techniques for facial wound healing, noting potential for stem cell therapies but highlighting the ongoing absence of skin features like hair follicles in cultured grafts.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    Nine years ago, the paper discussed the advancements and challenges in facial skin replacement techniques like allograft and autograft skin transplantation, particularly for burn or injury victims. Despite progress in transplantation, tissue engineering, and stem cell therapies, issues like the lack of hair follicles and sweat glands in cultured skin grafts persisted. The authors proposed that stem cells, due to their self-renewal and differentiation potential, could potentially reconstruct these missing structures within a wound. This insight could aid in the development of new therapies to address issues in facial wound healing.
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