TLDR Stem cells could potentially rebuild missing structures in wounds, improving facial skin replacement techniques.
Nine years ago, the paper discussed the advancements and challenges in facial skin replacement techniques like allograft and autograft skin transplantation, particularly for burn or injury victims. Despite progress in transplantation, tissue engineering, and stem cell therapies, issues like the lack of hair follicles and sweat glands in cultured skin grafts persisted. The authors proposed that stem cells, due to their self-renewal and differentiation potential, could potentially reconstruct these missing structures within a wound. This insight could aid in the development of new therapies to address issues in facial wound healing.
75 citations
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August 2008 in “PLOS ONE” Wnt3a protein, when packed in liposomal vesicles, can stimulate hair growth and could potentially treat conditions like hair loss.
829 citations
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May 2007 in “Nature” Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
85 citations
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October 2006 in “Current opinion in cell biology” Feather growth and regeneration involve complex patterns, stem cells, and evolutionary insights.
291 citations
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October 2005 in “Proceedings of the National Academy of Sciences of the United States of America” Adult stem cells from rat whisker follicles can regenerate hair follicles and sebaceous glands.
335 citations
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March 2004 in “Development” Temporary activation of β-catenin can create new hair follicles, but ongoing activation is needed to keep hair follicle tumors.
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January 2020 in “Stem Cells International” Epidermal stem cells help heal skin, but how they work is still unclear.
232 citations
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October 2015 in “International journal of molecular sciences” Stem cells are crucial for skin repair and new treatments for chronic wounds.
8 citations
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June 2015 in “Wound Repair and Regeneration” SCF helps heal diabetic wounds by promoting stem cell migration.
