New ethanol and propylene glycol free gel formulations containing a minoxidil-methyl-β-cyclodextrin complex as promising tools for alopecia treatment

    Nicola Margiotta, Annalisa Cutrignelli, Andreas Bernkop-Schnürch, Valentino Laquintana, Giuseppe Lopalco, Stefano Selva, Lorella Ragni, Serena Tongiani, Massimo Franco
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    TLDR New gel formulas without ethanol and propylene glycol, containing a minoxidil-methyl-β-cyclodextrin complex, have been created for treating hair loss.
    In 2015, researchers developed ethanol and propylene glycol-free gel formulations containing a minoxidil-methyl-β-cyclodextrin complex for alopecia treatment. These formulations were designed to improve minoxidil's low water solubility and ensure its adequate skin permeability. Four hydrogels were used to ensure prolonged scalp contact. The minoxidil/methyl-β-cyclodextrin complex was obtained by freeze drying and evaluated using NMR, FT-IR, and DSC analysis. The gels were tested for various technological parameters, including rheological behavior, in vitro drug release, and ex vivo permeation through pig skin. The calcium alginate formulation showed the best performance.
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