Neurosteroids And Epileptogenesis

    June 2013 in “ Journal of Neuroendocrinology ”
    Giuseppe Biagini, Cecilia Rustichelli, Giulia Curia … Stefano Meletti
    Studysummary This study suggests that neurosteroids, particularly allopregnanolone, may play a crucial role in the progression and management of epilepsy, as indicated by their effects on seizure modulation in both rats and humans.
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    Research cited in this study 6

    1. Temporal Lobe Epilepsy Exacerbation During Pharmacological Inhibition of Endogenous Neurosteroid Synthesis BMJ Case Reports · 2013
    2. Neurosteroids And Epileptogenesis In The Pilocarpine Model: Evidence For A Relationship Between P450scc Induction And Length Of The Latent Period Epilepsia · 2009
    3. Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism Biological & Pharmaceutical Bulletin · 2008
    4. Endogenous Neurosteroids Modulate Epileptogenesis in a Model of Temporal Lobe Epilepsy Experimental Neurology · 2006
    5. Anticonvulsant Activity of Progesterone and Neurosteroids in Progesterone Receptor Knockout Mice Journal of Pharmacology and Experimental Therapeutics · 2004
    6. Finasteride, a 5alpha-Reductase Inhibitor, Blocks the Anticonvulsant Activity of Progesterone in Mice PubMed · 1999

    Related research 1

    1. Finasteride Inhibits the Disease-Modifying Activity of Progesterone in the Hippocampus Kindling Model of Epileptogenesis Epilepsy & Behavior · 2012