The Role and Mechanism of Engineered Nanovesicles Derived from Hair Follicle Mesenchymal Stem Cells in the Treatment of UVB-Induced Skin Photoaging

The study investigates the therapeutic effects of engineered nanovesicles derived from hair follicle mesenchymal stem cells (HFMSC–CNVs) on UVB-induced skin photoaging. Using both in vivo (nude mice) and in vitro (human dermal fibroblasts) models, the research demonstrates that HFMSC–CNVs effectively reduce skin wrinkles, subcutaneous capillary dilation, epidermis thickening, and dermal thinning. They also enhance cellular activity, reduce reactive oxygen species (ROS) levels, and decrease cellular senescence. The nanovesicles promote cell proliferation, extracellular matrix production, and increase antioxidant enzyme activity, while downregulating proteins associated with cell cycle arrest and matrix degradation. These findings confirm the potential of HFMSC–CNVs as a treatment for skin photoaging by mitigating oxidative stress and promoting skin repair mechanisms.