TLDR Engineered nanovesicles from hair follicle stem cells can effectively treat UVB-induced skin aging.
The study explores the therapeutic potential of engineered nanovesicles derived from hair follicle mesenchymal stem cells (HFMSC–CNVs) in treating UVB-induced skin photoaging. Conducted on 40 nude mice, the research shows that HFMSC–CNVs, especially at higher doses, significantly improve skin conditions by reducing wrinkles, roughness, oxidative stress, and cellular senescence, while enhancing collagen expression and cell proliferation. These nanovesicles also alleviate UVB-induced cell cycle arrest and increase antioxidant enzyme expression. Despite the promising results, the study acknowledges limitations, such as the unidentified specific substances responsible for the effects and the lack of comparison with other vesicle types, suggesting HFMSC–CNVs as a potential treatment for skin photoaging.
22 citations
,
April 2022 in “Stem cell research & therapy” Hair follicle-derived extracellular vesicles may help heal chronic wounds as effectively as those from adipose tissue.
29 citations
,
January 2021 in “Journal of nanobiotechnology” Tiny particles from brain cells help hair grow by targeting a specific hair growth pathway.
90 citations
,
July 2020 in “Stem Cell Research & Therapy” Stem cell vesicles can reduce skin aging from UVB by lowering inflammation and oxidative stress.
93 citations
,
May 2002 in “Journal of Investigative Dermatology” Overexpressing thrombospondin-1 in mice skin prevents UVB-induced skin damage.
4 citations
,
December 2022 in “Frontiers in Bioengineering and Biotechnology” Exosomes show promise for improving wound healing, reducing aging signs, preventing hair loss, and lightening skin but require more research and better production methods.
10 citations
,
September 2021 in “International Journal of Nanomedicine” Tiny particles called extracellular vesicles show promise for treating skin conditions and promoting hair growth.
47 citations
,
February 2021 in “Pharmacological research” Exosomes can improve skin health and offer new treatments for skin repair and rejuvenation.
8 citations
,
June 2022 in “International Journal of Molecular Sciences” Tiny particles called extracellular vesicles show promise for skin improvement and anti-aging in facial care but face challenges like low production and lack of research.
January 2024 in “Journal of tissue engineering” Sunlight exposure damages hair follicles, but certain stem cell-derived particles can reduce this damage and help with hair regeneration.
